稳定期精神分裂症患者血浆细胞因子水平与认知功能的关系

中华行为医学与脑科学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1674-6554.2019.11.005

W. Feng, Q. Jia, Shuping Tan, Ting Yu, Jia Li, Zhiren Wang, Fude Yang, Li Tian, Yunlong Tan

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引用次数: 0

摘要

目的探讨稳定期精神分裂症患者血浆细胞因子水平与认知功能的关系，探讨细胞因子在其认知障碍发生机制中的可能作用。方法纳入符合DSM-IV精神障碍诊断标准的75例稳定期患者（患者组）和40例健康人（对照组）。采用酶联免疫吸附法（ELISA）检测各研究对象血浆促炎细胞因子IL-1β、IL-8、TNF-α和IFN-γ以及抗炎细胞因子IL-10的浓度。MATRICS共识认知电池（MCCB）用于评估患者的认知功能。比较患者组和对照组血浆细胞因子浓度的差异，分析血浆细胞因子与患者认知功能的关系。结果（1）患者组血浆IL-8（2.80（2.13）pg/ml vs 0.23（0.80）pgml）、TNF-α（1.16（0.47）pg/ml vs0.67（0.15）pg/ml）与对照组比较，差异有统计学意义（P<0.01），TNF-α与注意/警惕维度呈负相关（r=-0.29，P=0.03）。TNF-α水平与注意力/警惕维度之间存在相关性。此外，细胞因子水平的免疫异常可能在患者认知障碍的发展中发挥一定作用。关键词：稳定型精神分裂症；细胞因子；认知功能

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Relationship between plasma cytokine level and cognitive function in patients with stable schizophrenia

Objective To explore the relationship between plasma cytokine level and cognitive function in patients with stable schizophrenia and explore the possible role of cytokine in the occurrence mechanism of cognitive impairment in them. Methods A total of 75 stable patients who met the mental disorder diagnostic criteria of DSM-IV (patient group) and 40 healthy people (control group) were included in the essay.The method of enzymelinked immunosorbent assay (ELISA) were used to detected the concentrations of plasma proinflammatory cytokines IL-1β, IL-8, TNF-α and IFN-γ as well as the anti-inflammatory cytokines IL-10 in all research objects.The MATRICS Consensus Cognitive Battery (MCCB) was used to assess the cognitive function of patients.The relationship between plasma cytokines and cognitive function of patients were analyzed when the differences of the plasma cytokines concentrations were compared between the patient group and the control group. Results (1)Compared with the control group, plasma IL-8 (2.80(2.13)pg/ml vs 0.23 (0.80)pg/ml), TNF-α (1.16(0.47)pg/ml vs 0.67(0.15)pg/ml) in the patient group showed statistically significant difference (P<0.01). (2)In the partial correlation analysis of plasma cytokines and cognitive functions in patients, TNF-α was negatively correlated with the attention/vigilance dimensions(r=-0.29, P=0.03). Conclusion Stable schizophrenia patients have some problems with cytokine level.There is a correlation between TNF-α level and attention/vigilance dimensions.What's more, cytokine level immunological abnormalities may play some role in the development of cognitive impairment occurrence in patients. Key words: Stable schizophrenia; Cytokines; Cognitive function

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来源期刊

中华行为医学与脑科学杂志

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发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.