{"title":"肠道菌群与健忘轻度认知障碍患者内在脑活动的相互作用","authors":"Guoping Peng","doi":"10.1002/alz.042290","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients.</p>\n </section>\n \n <section>\n \n <h3> Method</h3>\n \n <p>Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, GM composition.</p>\n </section>\n \n <section>\n \n <h3> Result</h3>\n \n <p>aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different “GM–intrinsic brain activity interaction” patterns. In aMCI group, the relative abundance (RA) of Bacteroides from phylum to genus level was positively correlated with fALFF value in the right middle temporal gyrus in slow 4 and negatively with that of cerebellar vermis in typical band. The <i>Clostridiaceae</i> RA was positively correlated with the fALFF value of the right lingual gyrus in the typical band (0.01-0.08 Hz). The <i>Clostridiaceae</i> and <i>Blautia</i> RA was positively correlated with the fALFF value of the left cerebellum in slow 4 (0.027–0.073 Hz). At slow 5 (0.01–0.027 Hz), the Firmicutes RA was negatively correlated with the fALFF value in the right inferior frontal gyrus. Correlation analysis showed that Clostridium members (<i>Lachnospiraceae</i> and <i>Blautia</i>) were positively while <i>Veillonellaceae</i> was negatively linked with cognition test. While Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-step command score.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>aMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.</p>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"16 S4","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2020-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/alz.042290","citationCount":"0","resultStr":"{\"title\":\"Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment\",\"authors\":\"Guoping Peng\",\"doi\":\"10.1002/alz.042290\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Method</h3>\\n \\n <p>Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, GM composition.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Result</h3>\\n \\n <p>aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different “GM–intrinsic brain activity interaction” patterns. In aMCI group, the relative abundance (RA) of Bacteroides from phylum to genus level was positively correlated with fALFF value in the right middle temporal gyrus in slow 4 and negatively with that of cerebellar vermis in typical band. The <i>Clostridiaceae</i> RA was positively correlated with the fALFF value of the right lingual gyrus in the typical band (0.01-0.08 Hz). The <i>Clostridiaceae</i> and <i>Blautia</i> RA was positively correlated with the fALFF value of the left cerebellum in slow 4 (0.027–0.073 Hz). At slow 5 (0.01–0.027 Hz), the Firmicutes RA was negatively correlated with the fALFF value in the right inferior frontal gyrus. Correlation analysis showed that Clostridium members (<i>Lachnospiraceae</i> and <i>Blautia</i>) were positively while <i>Veillonellaceae</i> was negatively linked with cognition test. While Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-step command score.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>aMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.</p>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"16 S4\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2020-12-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1002/alz.042290\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.042290\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.042290","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment
Background
To explore the potential relationships among gut microbiota (GM), local brain spontaneous activity and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients.
Method
Twenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, GM composition.
Result
aMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different “GM–intrinsic brain activity interaction” patterns. In aMCI group, the relative abundance (RA) of Bacteroides from phylum to genus level was positively correlated with fALFF value in the right middle temporal gyrus in slow 4 and negatively with that of cerebellar vermis in typical band. The Clostridiaceae RA was positively correlated with the fALFF value of the right lingual gyrus in the typical band (0.01-0.08 Hz). The Clostridiaceae and Blautia RA was positively correlated with the fALFF value of the left cerebellum in slow 4 (0.027–0.073 Hz). At slow 5 (0.01–0.027 Hz), the Firmicutes RA was negatively correlated with the fALFF value in the right inferior frontal gyrus. Correlation analysis showed that Clostridium members (Lachnospiraceae and Blautia) were positively while Veillonellaceae was negatively linked with cognition test. While Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-step command score.
Conclusion
aMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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