氧化铁纳米颗粒及其在治疗her2阳性介导乳腺癌中的应用

Q3 Medicine
Dilpreet K Singh, B. Kurmi, GS Sarma, Sankha Bhattacharya, Sanjay A. Nagdev
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引用次数: 1

摘要

乳腺癌是全世界妇女死亡的第二大原因。转移的极快速度和对所有非传统治疗方法产生耐药性的倾向使其同样难以治疗,这是乳房黑色素瘤患者发病率和死亡率增加的原因。世界各地的专家都在关注首次发现乳房肿块,以便尽早采取措施。此外,传统的治疗方法,如化疗、放疗和局部手术治疗,都有一系列的缺点,包括毒性、正常细胞基因修饰和癌细胞扩散到健康组织。因此,对正常细胞毒性小的新治疗方案必须在很远的地方开发出来。氧化铁纳米颗粒仍广泛用于乳腺发育细胞的热靶向和成像。利用外部磁场,它们可以与药物、蛋白质、酶、抗体或核苷酸结合,并递送到目标器官、组织或恶性肿瘤。无论是在体内还是体外,氧化铁纳米颗粒都被发现是治疗乳腺癌的有效药物。此外,它们与药物或功能性生物分子的相互作用提高了药物传递效率,降低了药物的全身毒性。超顺磁性氧化铁纳米颗粒在乳腺疾病治疗的分析、行为和感知发展方面的多用途展示在本评估中被强调。由于其优异的超顺磁性、生物相容性和可生物降解性,被广泛应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Iron oxide nano particles and its applications to cure HER2-positive mediated breast cancer
Breast cancer is the second leading cause of death in women worldwide. The extremely rapid rate of metastasis and the propensity to develop resistance to all non-traditional treatments make them equally difficult to treat, which are the causes of increased morbidity and death in breast melanoma patients. Experts all around the world have been focusing on the first detection of a breast lump so that action can be taken at the earliest possible time. Furthermore, traditional treatment procedures such as chemotherapy, radiation, and local surgical treatment suffer from a slew of drawbacks, including toxicity, normal cell genetic modification, and cancer cell spread to healthy tissues. As a result, new therapy regimens with little toxicity to normal cells must be developed very away. Iron oxide nanoparticles are still widely utilized for heat targeting and imaging of breast development cells. Using an external magnetic field, they can be coupled with medicines, proteins, enzymes, antibodies, or nucleotides and delivered to target organs, tissues, or malignancies. Both in vitro and in vivo, iron oxide nanoparticles have been found to be effective as theranostics treating breast cancer. Furthermore, their interactions with pharmaceuticals or functional biomolecules improve drug delivery efficiency and reduce drug systemic toxicity. The multipurpose presentations of superparamagnetic iron oxide nanoparticles on the analysis, behavior, and perceiving development of breast disease remedy are emphasized in this assessment. Because of their remarkable superparamagnetic, biocompatible, and biodegradable qualities, they are widely used.
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来源期刊
Current Nanomedicine
Current Nanomedicine Medicine-Medicine (miscellaneous)
CiteScore
2.00
自引率
0.00%
发文量
15
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