血清白细胞介素33水平可作为银屑病诊断的新指标

IF 0.2 Q4 DERMATOLOGY
Mai AbdelWahed, M. Elmogy, M. Abdelsalam, M. Zohdy
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引用次数: 1

摘要

背景银屑病是一种Th1/Th17疾病,由角质形成细胞和免疫细胞之间的相互作用失调引起,导致皮肤过度增殖。据报道,在各种Th1/Th17驱动的自身免疫性疾病中,如类风湿性关节炎和炎症性肠病,白细胞介素(IL)-33水平升高,与疾病严重程度相关。据报道,银屑病患者的病变皮肤中IL-33水平升高。作者推测角质形成细胞释放的IL-33可能在银屑病的发病机制中发挥作用;因此,抑制IL-33活性可能是其治疗中一种突破性的新治疗策略。患者和方法采用酶联免疫吸附法测定30例活动性银屑病患者(A组)、30例稳定型银屑病患者(B组)和30例年龄匹配和性别匹配的健康对照组(组 C) 。结果银屑病患者血清IL-33平均值高于对照组,具有统计学意义。活动性银屑病患者的IL-33水平显著高于非活动性银屑病。此外,IL-33与银屑病面积和严重程度指数(PASI)评分之间存在统计学显著相关性。受试者操作特征曲线检测血清IL-33在区分银屑病患者和对照组中的有效性。在IL-33的截止点为22.72 pg/ml,预测银屑病的敏感性为96.67%,特异性为93.33%。血清IL-33是PASI评分的统计学显著预测因子,63.5%的PASI评分由血清IL-33预测。结论血清IL-33可能是银屑病诊断的新标志物,也是疾病严重程度的预测指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum interleukin-33 level may serve as a new marker for psoriasis diagnosis
Background Psoriasis is a Th1/Th17 disease resulting from a dysregulated interplay between keratinocytes and immune cells, leading to skin hyperproliferation. Increased levels of interleukin (IL)-33 were reported in various Th1/Th17-driven autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, with correlation to disease severity. Increased levels of IL-33 have been reported in lesional skin of psoriatic patients. The authors hypothesized that keratinocyte-released IL-33 might play a role in psoriasis pathogenesis; thus, inhibiting IL-33 activity might be a breaking new therapeutic strategy in its treatment. Patients and methods Serum IL-33 levels were measured by an enzyme-linked immunosorbent assay for 30 patients with active psoriasis (group A), 30 patient with stable psoriasis (group B), and 30 healthy age-matched and sex-matched controls (group C). Results Serum IL-33 showed statistically significant higher mean value among patients with psoriasis compared with the control group. The level of IL-33 in active psoriasis was significantly higher than in inactive psoriasis. Moreover, there was a statistically significant correlation between IL-33 and psoriasis area and severity index (PASI) score. Receiver operating characteristics curve detected the validity of serum IL-33 in differentiating patients with psoriasis from controls. At the cutoff point of IL-33 as 22.72 pg//ml, psoriasis could be predicted with 96.67% sensitivity and 93.33% specificity. Serum IL-33 was a statistically significant predictor of PASI score, with 63.5% of PASI scores predicted by serum IL-33. Conclusion Serum IL-33 may represent a new marker for psoriasis diagnosis as well as a predictor of the disease severity.
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