{"title":"用于生物医学应用的生物陶瓷羟基磷灰石的合成技术","authors":"T. O. Sadiq, I. Sudin, J. Idris, N. A. Fadil","doi":"10.4028/p-yqw75e","DOIUrl":null,"url":null,"abstract":"The need to develop surviving implants and bone substitutes with good biocompatibility, mechanical strength and bioactivity, without causing toxicity, immune rejection and cancer had attracted the attention of many researchers over the years. Hydroxyapatite (HA) is one of the excellent calcium phosphates and major mineral component of vertebrate bone and teeth, which considerably enhances the biocompatibility, mechanical strength and bioactivity of artificial biomaterials in the body system. In addition, it creates porous and rough coated surface that aids the cell attachment, proliferation and the growth of tissue on the bone implants. Due to its high demand in biomedical applications, scientists had developed several, simple and efficient techniques to produce HA. This review outlines several techniques of manufacturing HA and summarizes the merits and demerits of each technique. Keywords: Biomaterials, calcium phosphate, hydroxyapatite, preparation techniques and bone","PeriodicalId":15161,"journal":{"name":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","volume":"59 1","pages":"59 - 80"},"PeriodicalIF":0.5000,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Synthesis Techniques of Bioceramic Hydroxyapatite for Biomedical Applications\",\"authors\":\"T. O. Sadiq, I. Sudin, J. Idris, N. A. Fadil\",\"doi\":\"10.4028/p-yqw75e\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The need to develop surviving implants and bone substitutes with good biocompatibility, mechanical strength and bioactivity, without causing toxicity, immune rejection and cancer had attracted the attention of many researchers over the years. Hydroxyapatite (HA) is one of the excellent calcium phosphates and major mineral component of vertebrate bone and teeth, which considerably enhances the biocompatibility, mechanical strength and bioactivity of artificial biomaterials in the body system. In addition, it creates porous and rough coated surface that aids the cell attachment, proliferation and the growth of tissue on the bone implants. Due to its high demand in biomedical applications, scientists had developed several, simple and efficient techniques to produce HA. This review outlines several techniques of manufacturing HA and summarizes the merits and demerits of each technique. Keywords: Biomaterials, calcium phosphate, hydroxyapatite, preparation techniques and bone\",\"PeriodicalId\":15161,\"journal\":{\"name\":\"Journal of Biomimetics, Biomaterials and Biomedical Engineering\",\"volume\":\"59 1\",\"pages\":\"59 - 80\"},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2023-02-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Biomimetics, Biomaterials and Biomedical Engineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4028/p-yqw75e\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Biomimetics, Biomaterials and Biomedical Engineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4028/p-yqw75e","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Synthesis Techniques of Bioceramic Hydroxyapatite for Biomedical Applications
The need to develop surviving implants and bone substitutes with good biocompatibility, mechanical strength and bioactivity, without causing toxicity, immune rejection and cancer had attracted the attention of many researchers over the years. Hydroxyapatite (HA) is one of the excellent calcium phosphates and major mineral component of vertebrate bone and teeth, which considerably enhances the biocompatibility, mechanical strength and bioactivity of artificial biomaterials in the body system. In addition, it creates porous and rough coated surface that aids the cell attachment, proliferation and the growth of tissue on the bone implants. Due to its high demand in biomedical applications, scientists had developed several, simple and efficient techniques to produce HA. This review outlines several techniques of manufacturing HA and summarizes the merits and demerits of each technique. Keywords: Biomaterials, calcium phosphate, hydroxyapatite, preparation techniques and bone