通过调控MLC2/FAK/Akt信号通路刺激局灶细胞粘附的新作用

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Cell Adhesion & Migration Pub Date : 2022-05-26 DOI:10.1080/19336918.2022.2073002

Su jin Lee, Ji Eun Kim, J. W. Jung, Y. Choi, J. Gong, Bounleuane Douangdeuane, Onevilay Souliya, Y. Choi, Sung Baek Seo, D. Hwang

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引用次数: 4

摘要

摘要为了研究结核龙脑香对局灶细胞粘附刺激的新功能，分析了用结核龙脑花甲醇提取物（MED）处理后NHDF细胞和颅骨缺损大鼠模型中局灶细胞黏附相关因子的调节变化。MED含有高浓度的没食子酸、咖啡酸、鞣花酸和柚皮素。MED增强了NHDF细胞的增殖活性、局灶细胞粘附能力、粘附受体介导的信号通路。此外，在颅骨再生过程中，MED涂层钛板（MEDTiP）表面上检测到致密的粘附组织层和粘附细胞。本研究的结果提供了新的证据，证明MED可以刺激NHDF细胞和颅骨缺损大鼠模型中的局灶细胞粘附。

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Novel role of Dipterocarpus tuberculatus as a stimulator of focal cell adhesion through the regulation of MLC2/FAK/Akt signaling pathway

ABSTRACT To investigate a novel function of Dipterocarpus tuberculatus on focal cell adhesion stimulation, alterations to the regulation of focal cell adhesion-related factors were analyzed in NHDF cells and a calvarial defect rat model after treatment with methanol extracts of D. tuberculatus (MED). MED contained gallic acid, caffeic acid, ellagic acid, and naringenin in high concentrations. The proliferation activity, focal cell adhesion ability, adhesion receptors-mediated signaling pathway in NHDF cells were increased by MED. Also, a dense adhered tissue layer and adherent cells on MED-coated titanium plate (MEDTiP) surfaces were detected during regeneration of calvarial bone. The results of the present study provide novel evidence that MED may stimulate focal cell adhesion in NHDF cells and a calvarial defect rat model.

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来源期刊

Cell Adhesion & Migration CELL BIOLOGY-

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

53 weeks

期刊介绍： Cell Adhesion & Migration is a multi-disciplinary, peer reviewed open access journal that focuses on the biological or pathological implications of cell-cell and cell-microenvironment interactions. The main focus of this journal is fundamental science. The journal strives to serve a broad readership by regularly publishing review articles covering specific disciplines within the field, and by publishing focused issues that provide an overview on specific topics of interest within the field. Cell Adhesion & Migration publishes relevant and timely original research, as well as authoritative overviews, commentaries, and perspectives, providing context for the work presented in Cell Adhesion & Migration and for key results published elsewhere. Original research papers may cover all topics important in the field of cell-cell and cell-matrix interactions. Cell Adhesion & Migration also publishes articles related to cell biomechanics, biomaterial, and development of related imaging technologies.