药用植物中生物活性物质的合成与生产策略

IF 4.7 4区 医学 Q1 CHEMISTRY, MEDICINAL
Miaoxian Guo , Haizhou Lv , Hongyu Chen , Shuting Dong , Jianhong Zhang , Wanjing Liu , Liu He , Yimian Ma , Hua Yu , Shilin Chen , Hongmei Luo
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引用次数: 0

摘要

药用植物是医疗保健和疾病治疗所需的基本药物和草药产品的宝贵来源。与化学合成和提取相比,天然产物的生物合成是成功保护药用植物的一种非常有前景的替代方法,它的快速发展将极大地促进药用植物的保护和可持续利用。在此,我们总结了有关药用植物天然产物生物合成和生产的策略和方法的进展。这些策略和方法主要包括基因工程、植物细胞培养工程、代谢工程和基于多种 "OMICS "技术的合成生物学,以及萜类化合物和生物碱的生物合成范例。我们还重点介绍了生物合成方法,并讨论了一些有价值的天然产品的生产进展,例如吲哚啉(生物碱)、青蒿素和紫杉醇(萜类化合物)等化合物,以说明生物技术在药用植物中的力量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Strategies on biosynthesis and production of bioactive compounds in medicinal plants

Medicinal plants are a valuable source of essential medicines and herbal products for healthcare and disease therapy. Compared with chemical synthesis and extraction, the biosynthesis of natural products is a very promising alternative for the successful conservation of medicinal plants, and its rapid development will greatly facilitate the conservation and sustainable utilization of medicinal plants. Here, we summarize the advances in strategies and methods concerning the biosynthesis and production of natural products of medicinal plants. The strategies and methods mainly include genetic engineering, plant cell culture engineering, metabolic engineering, and synthetic biology based on multiple “OMICS” technologies, with paradigms for the biosynthesis of terpenoids and alkaloids. We also highlight the biosynthetic approaches and discuss progress in the production of some valuable natural products, exemplifying compounds such as vindoline (alkaloid), artemisinin and paclitaxel (terpenoids), to illustrate the power of biotechnology in medicinal plants.

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来源期刊
Chinese Herbal Medicines
Chinese Herbal Medicines CHEMISTRY, MEDICINAL-
CiteScore
4.40
自引率
5.30%
发文量
629
审稿时长
10 weeks
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