2-氯-5-硝基苯甲酸及杂环化合物三元金属配合物的合成、晶体结构、热行为及抗肿瘤活性

IF 1.3 3区 化学 Q3 CHEMISTRY, ORGANIC
Zhongyu Zhang, Meng Chen, M. Tong, Wan Sun, P. Dong, Xinfeng Song, Xiaoyue Wang
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引用次数: 2

摘要

摘要合成了三种配合物,即配合物(1)、配合物(2)和配合物(3),并通过X射线衍射、热重分析和元素分析对其进行了表征。络合物(1)包括离散的双核簇,其中2-氯-5-硝基苯甲酸的两个氧原子桥接两个铜原子。配合物(2)是由2-氯-5-硝基苯甲酸和1,10-菲罗啉中的四个氮原子和两个氧原子组成的六配位结构,形成扭曲的八面体。配合物(3)是一种六配位结构,由2-氯-5-硝基苯甲酸、甲醇和2,2′-联吡啶的四个氧原子和两个氮原子组成,形成扭曲的八面体几何结构。MTT法检测金属配合物的抗肿瘤活性。在测试的复合物中,复合物(1)可诱导这些A549肺癌癌症和Caco-2结肠癌细胞的凋亡,复合物可诱导Caco-2结肠腺癌细胞的凋亡。复合体(1)的CCDC为1543354,复合体(2)的CCDC1546991,复合体(3)的CCCCDC1543417。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Syntheses, crystal structure, thermal behavior, and anti-tumor activity of three ternary metal complexes with 2-chloro-5-nitrobenzoic acid and heterocyclic compounds
Abstract Three complexes, namely complex (1), complex (2), and complex (3), were synthesized and characterized by X-ray diffraction, thermogravimetric study, and elemental study. Complex (1) comprises discrete binuclear clusters, where two oxygen atoms of 2-chloro-5-nitrobenzoic acid bridge the two copper atoms. Complex (2) is a six-coordination structure consisting of four nitrogen atoms and two oxygen atoms in 2-chloro-5-nitrobenzoic acid and 1,10-phenanthroline to furnish a twisted octahedron. Complex (3) is a six-coordination structure consisting of four oxygen atoms and two nitrogen atoms from the 2-chloro-5-nitrobenzoic acid, methanol, and 2,2′-dipyridyl to furnish a distorted octahedral geometry. Metal complexes’ anti-tumor activity was also investigated by the MTT assay. Of the complexes tested, complex (1) could induce apoptosis in these A549 lung cancer and Caco-2 colon adenocarcinoma cells and complex (2) could induce apoptosis in Caco-2 colon adenocarcinoma cells. CCDC for complex (1) was 1543354, CCDC for complex (2) was 1546991, and CCDC for complex (3) was 1543417.
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来源期刊
Heterocyclic Communications
Heterocyclic Communications 化学-有机化学
CiteScore
3.80
自引率
4.30%
发文量
13
审稿时长
1.4 months
期刊介绍: Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.
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