A. Shater, Fayez M. Saleh, Zuhair M. Mohammedsaleh, H. Gattan, Bassam M. Al-ahmadi, N. Saeedi, M. Jalal, C. Panneerselvam
{"title":"治疗疟疾的银纳米晶体的绿色纳米结构及其对肾Vero细胞系的细胞毒性作用","authors":"A. Shater, Fayez M. Saleh, Zuhair M. Mohammedsaleh, H. Gattan, Bassam M. Al-ahmadi, N. Saeedi, M. Jalal, C. Panneerselvam","doi":"10.1515/gps-2022-8111","DOIUrl":null,"url":null,"abstract":"Abstract This study focused on testing manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and the malaria vector Anopheles stephensi using the plant filtrate from Madhuca longifolia. The M. longifolia leaf extracts were used to synthesize the AgNPs, which were then subjected to several physicochemical methods to determine their characteristics. To evaluate the effectiveness of the green produced AgNP therapy, the mosquitocidal activity of A. stephensi, cytotoxicity assay in Vero cells, and antiplasmodial activity assay were performed. The larval and pupal toxicity of biosynthesized AgNPs against the malarial vector A. stephensi is 90% promising in laboratory settings at low dosages (10 ppm). When tested on African green monkey kidney cells, the cytotoxic effect of biosynthesized materials was found to be inappropriately damaging up to 100 g·mL−1. The antimalarial efficacy of AgNPs was evaluated against P. falciparum strains. The parasites that were restrained by AgNPs at 100 ppm had the highest parasitemia restraint rate (80.4%). AgNPs then showed significant in vitro antimalarial activity against P. falciparum. Our findings suggested that the biosynthesized AgNPs might function as a novel antimalarial agent that is both safer for the environment and a barrier to infections spread by mosquitoes. Graphical abstract Illustration of AgNP synthesis in the fight against malaria.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":3.8000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Green nanoarchitectonics of the silver nanocrystal potential for treating malaria and their cytotoxic effects on the kidney Vero cell line\",\"authors\":\"A. Shater, Fayez M. Saleh, Zuhair M. Mohammedsaleh, H. Gattan, Bassam M. Al-ahmadi, N. Saeedi, M. Jalal, C. Panneerselvam\",\"doi\":\"10.1515/gps-2022-8111\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract This study focused on testing manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and the malaria vector Anopheles stephensi using the plant filtrate from Madhuca longifolia. The M. longifolia leaf extracts were used to synthesize the AgNPs, which were then subjected to several physicochemical methods to determine their characteristics. To evaluate the effectiveness of the green produced AgNP therapy, the mosquitocidal activity of A. stephensi, cytotoxicity assay in Vero cells, and antiplasmodial activity assay were performed. The larval and pupal toxicity of biosynthesized AgNPs against the malarial vector A. stephensi is 90% promising in laboratory settings at low dosages (10 ppm). When tested on African green monkey kidney cells, the cytotoxic effect of biosynthesized materials was found to be inappropriately damaging up to 100 g·mL−1. The antimalarial efficacy of AgNPs was evaluated against P. falciparum strains. The parasites that were restrained by AgNPs at 100 ppm had the highest parasitemia restraint rate (80.4%). AgNPs then showed significant in vitro antimalarial activity against P. falciparum. Our findings suggested that the biosynthesized AgNPs might function as a novel antimalarial agent that is both safer for the environment and a barrier to infections spread by mosquitoes. Graphical abstract Illustration of AgNP synthesis in the fight against malaria.\",\"PeriodicalId\":12758,\"journal\":{\"name\":\"Green Processing and Synthesis\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.8000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Green Processing and Synthesis\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1515/gps-2022-8111\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Green Processing and Synthesis","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1515/gps-2022-8111","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Green nanoarchitectonics of the silver nanocrystal potential for treating malaria and their cytotoxic effects on the kidney Vero cell line
Abstract This study focused on testing manufactured silver nanoparticles (AgNPs) against the malaria pathogen Plasmodium falciparum and the malaria vector Anopheles stephensi using the plant filtrate from Madhuca longifolia. The M. longifolia leaf extracts were used to synthesize the AgNPs, which were then subjected to several physicochemical methods to determine their characteristics. To evaluate the effectiveness of the green produced AgNP therapy, the mosquitocidal activity of A. stephensi, cytotoxicity assay in Vero cells, and antiplasmodial activity assay were performed. The larval and pupal toxicity of biosynthesized AgNPs against the malarial vector A. stephensi is 90% promising in laboratory settings at low dosages (10 ppm). When tested on African green monkey kidney cells, the cytotoxic effect of biosynthesized materials was found to be inappropriately damaging up to 100 g·mL−1. The antimalarial efficacy of AgNPs was evaluated against P. falciparum strains. The parasites that were restrained by AgNPs at 100 ppm had the highest parasitemia restraint rate (80.4%). AgNPs then showed significant in vitro antimalarial activity against P. falciparum. Our findings suggested that the biosynthesized AgNPs might function as a novel antimalarial agent that is both safer for the environment and a barrier to infections spread by mosquitoes. Graphical abstract Illustration of AgNP synthesis in the fight against malaria.
期刊介绍:
Green Processing and Synthesis is a bimonthly, peer-reviewed journal that provides up-to-date research both on fundamental as well as applied aspects of innovative green process development and chemical synthesis, giving an appropriate share to industrial views. The contributions are cutting edge, high-impact, authoritative, and provide both pros and cons of potential technologies. Green Processing and Synthesis provides a platform for scientists and engineers, especially chemists and chemical engineers, but is also open for interdisciplinary research from other areas such as physics, materials science, or catalysis.