双相情感障碍的神经分子病因学:情绪稳定剂可能的治疗靶点

IF 2.4 4区医学 Q3 NEUROSCIENCES

Clinical Psychopharmacology and Neuroscience Pub Date : 2022-05-31 DOI:10.9758/cpn.2022.20.2.228

J. G. Lee, Y. Woo, S. Park, D. Seog, M. Seo, W. Bahk

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引用次数: 4

摘要

双相情感障碍是一种导致极端情绪波动的精神疾病，具有慢性病程。然而，在双相情感障碍患者中，完全相反特征的情绪发作反复出现或症状混合出现的机制尚不清楚。因此，情绪稳定剂仅适用于单一情绪发作，如躁狂发作和抑郁发作，目前还没有真正的既能治疗躁狂发作又能治疗抑郁发作的情绪稳定药物。因此，在这篇综述中，通过回顾目前对双相情感障碍神经分子病因的理解，研究了促进情绪稳定剂发展的治疗靶点。

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Neuromolecular Etiology of Bipolar Disorder: Possible Therapeutic Targets of Mood Stabilizers

Bipolar disorder is a mental illness that causes extreme mood swings and has a chronic course. However, the mechanism by which mood episodes with completely opposite characteristics appear repeatedly, or a mixture of symptoms appears, in patients with bipolar disorder remains unknown. Therefore, mood stabilizers are indicated only for single mood episodes, such as manic episodes and depressive episodes, and no true mood-stabilizing drugs effective for treating both manic and depressive episodes currently exist. Therefore, in this review, therapeutic targets that facilitate the development of mood stabilizers were examined by reviewing the current understanding of the neuromolecular etiology of bipolar disorder.

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来源期刊

Clinical Psychopharmacology and Neuroscience NEUROSCIENCESPHARMACOLOGY & PHARMACY-PHARMACOLOGY & PHARMACY

CiteScore

4.70

自引率

12.50%

发文量

期刊介绍： Clinical Psychopharmacology and Neuroscience (Clin Psychopharmacol Neurosci) launched in 2003, is the official journal of The Korean College of Neuropsychopharmacology (KCNP), and the associate journal for Asian College of Neuropsychopharmacology (AsCNP). This journal aims to publish evidence-based, scientifically written articles related to clinical and preclinical studies in the field of psychopharmacology and neuroscience. This journal intends to foster and encourage communications between psychiatrist, neuroscientist and all related experts in Asia as well as worldwide. It is published four times a year at the last day of February, May, August, and November.