{"title":"纳米结构脂质载体在难溶性药物口服递送中的潜力","authors":"Manasi Jiwankar, Vidya Sabale","doi":"10.1007/s11051-023-05840-0","DOIUrl":null,"url":null,"abstract":"<p>The oral route is one of the most preferred routes of administration because of its convenience and safety. Nanostructured lipid carriers (NLCs) are the second-generation nanosize solid lipid nanocarriers that are composed of solid lipids, liquid lipids, and surfactants. The lipid matrix of NLCs has an imperfect structure which allows more drug loading. Other advantages offered by NLCs include biocompatibility, biodegradability, and high encapsulation efficiency. They are considered potential nanocarriers in oral drug delivery and have particle size in the range of 50–300 nm. NLCs have shown improved oral bioavailability of lipophilic drugs. They also bypass first-pass metabolism and inhibit the P-glycoprotein (P-gp) efflux mechanism of drugs. This review mainly highlights the role of NLCs in the oral delivery of drugs and different barriers that have to be overcome to achieve drug delivery by oral route.</p>","PeriodicalId":653,"journal":{"name":"Journal of Nanoparticle Research","volume":"25 9","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Potential of nanostructured lipid carriers in oral delivery of the poorly soluble drugs\",\"authors\":\"Manasi Jiwankar, Vidya Sabale\",\"doi\":\"10.1007/s11051-023-05840-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The oral route is one of the most preferred routes of administration because of its convenience and safety. Nanostructured lipid carriers (NLCs) are the second-generation nanosize solid lipid nanocarriers that are composed of solid lipids, liquid lipids, and surfactants. The lipid matrix of NLCs has an imperfect structure which allows more drug loading. Other advantages offered by NLCs include biocompatibility, biodegradability, and high encapsulation efficiency. They are considered potential nanocarriers in oral drug delivery and have particle size in the range of 50–300 nm. NLCs have shown improved oral bioavailability of lipophilic drugs. They also bypass first-pass metabolism and inhibit the P-glycoprotein (P-gp) efflux mechanism of drugs. This review mainly highlights the role of NLCs in the oral delivery of drugs and different barriers that have to be overcome to achieve drug delivery by oral route.</p>\",\"PeriodicalId\":653,\"journal\":{\"name\":\"Journal of Nanoparticle Research\",\"volume\":\"25 9\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2023-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Nanoparticle Research\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11051-023-05840-0\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Nanoparticle Research","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1007/s11051-023-05840-0","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Potential of nanostructured lipid carriers in oral delivery of the poorly soluble drugs
The oral route is one of the most preferred routes of administration because of its convenience and safety. Nanostructured lipid carriers (NLCs) are the second-generation nanosize solid lipid nanocarriers that are composed of solid lipids, liquid lipids, and surfactants. The lipid matrix of NLCs has an imperfect structure which allows more drug loading. Other advantages offered by NLCs include biocompatibility, biodegradability, and high encapsulation efficiency. They are considered potential nanocarriers in oral drug delivery and have particle size in the range of 50–300 nm. NLCs have shown improved oral bioavailability of lipophilic drugs. They also bypass first-pass metabolism and inhibit the P-glycoprotein (P-gp) efflux mechanism of drugs. This review mainly highlights the role of NLCs in the oral delivery of drugs and different barriers that have to be overcome to achieve drug delivery by oral route.
期刊介绍：
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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