听力损失增加前额皮质刺激对内侧膝状核声诱发活动的抑制作用

IF 2.8 4区 医学 Q2 NEUROSCIENCES
Frontiers in Synaptic Neuroscience Pub Date : 2022-03-01 eCollection Date: 2022-01-01 DOI:10.3389/fnsyn.2022.840368
Chenae De Vis, Kristin M Barry, Wilhelmina H A M Mulders
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引用次数: 0

摘要

感觉门控是一种不相关的感觉刺激在向高级皮质区域传递的过程中被抑制,从而使人们能够专注于显著信息的过程。感觉门控回路包括丘脑和几个皮层区域,包括前额叶皮层(PFC)。感觉门控缺陷与一系列神经系统疾病有关,包括耳鸣,一种与耳蜗损伤密切相关的幻听知觉。最近,我们在大鼠实验中发现,耳蜗损伤后,PFC与听觉丘脑(即内侧膝状核(MGN))之间的功能连通性发生了变化,表明PFC激活对MGN神经元自发放电率的抑制作用增强。在这项研究中,我们使用豚鼠模型进一步研究了这一现象,以证明我们的发现超越了单一物种的有效性,并将数据扩展到包括声音诱发反应的数据。实验记录了PFC电刺激对听力正常或听力丧失的豚鼠在听觉创伤后2周的麻醉状态下大网膜单神经元自发活动和声诱发活动的影响。PFC刺激后未观察到任何影响、抑制和兴奋。在听力正常和听力损失的动物中,这些影响的比例没有差异,但影响的大小不同。的确,听力损失显著增加了对声音诱发反应的抑制程度,但对自发活动没有影响。这些发现支持了先前的观察结果,即耳蜗损伤后PFC可以调节MGN的活动,并在这一途径中发生功能变化。这些数据表明听力损失可以改变感觉门控,这可能是耳鸣发展的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hearing Loss Increases Inhibitory Effects of Prefrontal Cortex Stimulation on Sound Evoked Activity in Medial Geniculate Nucleus.

Sensory gating is the process whereby irrelevant sensory stimuli are inhibited on their way to higher cortical areas, allowing for focus on salient information. Sensory gating circuitry includes the thalamus as well as several cortical regions including the prefrontal cortex (PFC). Defective sensory gating has been implicated in a range of neurological disorders, including tinnitus, a phantom auditory perception strongly associated with cochlear trauma. Recently, we have shown in rats that functional connectivity between PFC and auditory thalamus, i.e., the medial geniculate nucleus (MGN), changes following cochlear trauma, showing an increased inhibitory effect from PFC activation on the spontaneous firing rate of MGN neurons. In this study, we further investigated this phenomenon using a guinea pig model, in order to demonstrate the validity of our finding beyond a single species and extend data to include data on sound evoked responses. Effects of PFC electrical stimulation on spontaneous and sound-evoked activity of single neurons in MGN were recorded in anaesthetised guinea pigs with normal hearing or hearing loss 2 weeks after acoustic trauma. No effect, inhibition and excitation were observed following PFC stimulation. The proportions of these effects were not different in animals with normal hearing and hearing loss but the magnitude of effect was. Indeed, hearing loss significantly increased the magnitude of inhibition for sound evoked responses, but not for spontaneous activity. The findings support previous observations that PFC can modulate MGN activity and that functional changes occur within this pathway after cochlear trauma. These data suggest hearing loss can alter sensory gating which may be a contributing factor toward tinnitus development.

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来源期刊
CiteScore
7.10
自引率
2.70%
发文量
74
审稿时长
14 weeks
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