蜜瓜代谢谱、环多元醇的分离、抗氧化和抗炎活性:基于NMR和GC-MS的代谢组学研究

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2020-07-05 DOI:10.1080/10496475.2020.1786873

Ritu Tiwari, Tusha Tripathi, Y. Khan, Annie Gupta, M. Dhobi, S. Srivastava, Brahma N. Singh, K. Shanker, V. Kalaiselvan, G. Singh

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引用次数: 8

摘要

摘要分离了蜜瓜不同部位的初级和次级代谢产物，并对其环多元醇进行了表征。测定了体外和人肝脏AML-12细胞的抗氧化活性以及奎宁酸和乙醇提取物的抗炎活性。通过HPLC、GC-MS、NMR等方法鉴定出132种主要代谢物和次级代谢物。结果表明，蜜瓜是一种抗氧化剂和可持续的副产物，具有治疗炎症的潜力。

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Metabolite Profiling, Isolation of Cyclic Polyols, Antioxidant and Anti-inflammatory Activities of Aegle Marmelos: NMR and GC-MS Based Metabolomics Study

ABSTRACT The primary and secondary metabolites of different parts of Aegle marmelos were isolated, the cyclic polyols were characterized. The antioxidant activities in vitro and in a cell-based human liver AML-12 cells and the anti-inflammatory activities of isolated quinic acid and ethanol extract of leaves were determined. One hundred and thirty two primary and secondary metabolites were identified in the extracts by HPLC, GC-MS, and NMR. Results demonstrated A. marmelos as an antioxidant and a sustainable by-product with therapeutic potential for treating inflammation.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.