不同盐酸雷洛昔芬脂聚合物杂化纳米颗粒的制备、表征及比较

Q4 Chemistry

International Journal of Nano and Biomaterials Pub Date : 2020-12-28 DOI:10.1504/ijnbm.2020.10034537

S. Mahmood, Tan Cheh Phey, Lee Seow Kheng, Ke Chen, U. Mandal

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引用次数: 1

摘要

本研究旨在制备雷洛昔芬负载的脂质-聚合物杂化纳米颗粒（LPHNPs）并对其性能进行比较。通过纳米沉淀、溶剂注入和乳液溶剂蒸发分别制备了三种LPHNP，每种LPHNPs都以磷脂酰胆碱脂质（PCL）为双层膜，并与三种不同的聚合物（如藻酸钠、壳聚糖和聚乳酸-乙醇酸）形成膜。结果表明，制备的制剂呈球形，具有不均匀性。使用扫描电子显微镜（SEM）观察表面形态。使用数学动力学模型观察和评估了24小时的高包封率（>70%）和持续的pH依赖性药物释放曲线。在评估所用赋形剂的相互作用和兼容性后，使用傅里叶变换红外光谱来确认雷洛昔芬的成功包封。然而，差示扫描量热法和X射线衍射揭示了雷洛昔芬向无定形形式的转变。总之，这些杂化纳米颗粒为雷洛昔芬经口给药提供了一种很有前途的方法。

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Formulation, characterisation and comparison of different raloxifene hydrochloride loaded lipid-polymer hybrid nanoparticles

This study aims to formulate raloxifene loaded lipid-polymeric hybrid nanoparticles (LPHNPs) and the comparison of their properties. Three LPHNPs, each with phosphatidylcholine-lipid (PCL) as bilayer-forming-membrane with three different polymers like sodium alginate, chitosan and poly(lactic-co-glycolic-acid) were prepared by nanoprecipitation, solvent injection and emulsion solvent evaporation, respectively. Results showed that the prepared formulations were spherical-shaped with a heterogeneity. Surface morphology was viewed using a scanning electron microscopy (SEM). A high entrapment efficiency (>70%) with a sustained and pH dependent drug release profile for 24 h was observed and evaluated using mathematical kinetic modelling. Fourier transform infrared spectroscopy was used to confirm successful entrapment of raloxifene after evaluating the interaction and compatibility of the excipients used. Whereas, differential scanning calorimetry and X-ray diffraction revealed the transformation of raloxifene into an amorphous form. In conclusion, these hybrid nanoparticles provide a promising approach for oral delivery of raloxifene.

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来源期刊

International Journal of Nano and Biomaterials Chemistry-Physical and Theoretical Chemistry

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： In recent years, frontiers of research in engineering, science and technology have been driven by developments in nanomaterials, encompassing a diverse range of disciplines such as materials science, biomedical engineering, nanomedicine and biology, manufacturing technology, biotechnology, nanotechnology, and nanoelectronics. IJNBM provides an interdisciplinary vehicle covering these fields. Advanced materials inspired by biological systems and processes are likely to influence the development of novel technologies for a wide variety of applications from vaccines to artificial tissues and organs to quantum computers. Topics covered include Nanostructured materials/surfaces/interfaces Synthesis of nanostructures Biological/biomedical materials Artificial organs/tissues Tissue engineering Bioengineering materials Medical devices Functional/structural nanomaterials Carbon-based materials Nanomaterials characterisation Novel applications of nanomaterials Modelling of behaviour of nanomaterials Nanomaterials for biomedical applications Biological response to nanomaterials.