在被诊断为潜伏性结核病的HIV感染患者中进行异烟肼预防性治疗的抗逆转录病毒治疗：坦桑尼亚结果的回顾性评估

Q3 Medicine

Indian Journal of Tuberculosis Pub Date : 2025-01-01 DOI:10.1016/j.ijtb.2023.07.005

Karol J Marwa , Rachel Maingu

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Isoniazid preventive therapy among HIV infected patients on antiretroviral therapy diagnosed with latent tuberculosis: A retrospective assessment of the outcome in Tanzania

Background

People infected with HIV are at a higher risk up to 20-folds of developing active TB than those not infected with HIV. Isoniazid Preventive Therapy (IPT) is employed in HIV eligible individuals to prevent progression of active tuberculosis (TB) disease. However, there is limited data on the efficacy of IPT in clinical settings in Tanzania and other parts of the world. This study was carried to assess the real-time IPT effectiveness in preventing TB incidences among HIV infected individuals on antiretroviral therapy.

Methods

A retrospective cohort study was carried employing secondary data of 1000 HIV infected individuals receiving anti-retroviral therapy. TB incidence and associated factors were determined after a four years follow-up.

Results

A total of 1000 people were enrolled in the study. The mean age was 44.87 years. The incidence rate was 7.37/1000 person-years (PY) [95% confidence interval (CI) 3.96-13.71]. One percent (1%) of patients developed active tuberculosis within four years of follow up after receiving isoniazid tablets as part of IPT.

Conclusion

IPT has a high efficacy in preventing active TB development among HIV infected individuals on ART in clinical settings thus warranting the scale up of IPT services in the country.

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来源期刊

Indian Journal of Tuberculosis Medicine-Infectious Diseases

CiteScore

2.80

自引率

0.00%

发文量

103

期刊介绍： Indian Journal of Tuberculosis (IJTB) is an international peer-reviewed journal devoted to the specialty of tuberculosis and lung diseases and is published quarterly. IJTB publishes research on clinical, epidemiological, public health and social aspects of tuberculosis. The journal accepts original research articles, viewpoints, review articles, success stories, interesting case series and case reports on patients suffering from pulmonary, extra-pulmonary tuberculosis as well as other respiratory diseases, Radiology Forum, Short Communications, Book Reviews, abstracts, letters to the editor, editorials on topics of current interest etc. The articles published in IJTB are a key source of information on research in tuberculosis. The journal is indexed in Medline