番荔枝科植物的乙酰素:有效的抗肿瘤和神经毒性化合物

IF 2.4 Q3 NUTRITION & DIETETICS
Naiara Nascimento das Chagas Lima , Denise Carreiro Faustino , Kyan James Allahdadi , Luciana Souza de Aragão França , Laise Cedraz Pinto
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引用次数: 5

摘要

醋酸原素是番荔枝科植物中发现的具有细胞毒性的化合物,具有抗增殖和抗肿瘤作用。然而,它们也与非典型帕金森病相关的神经毒性作用有关。本研究旨在进行系统回顾,并确定肿瘤细胞和神经毒性乙酰原的细胞毒性和选择机制。方法对乙酰原对肿瘤细胞和神经毒性乙酰原的细胞毒性和选择性机制进行系统综述。结果其抗肿瘤作用机制主要是通过细胞凋亡作用、肿瘤生长因子负调控作用和遗传毒性作用。已证实的神经毒性机制是通过抑制神经元线粒体复合体I和tau蛋白功能障碍。Acetogenins显示出准时和选择性的抗癌作用,尽管其选择性尚不清楚,并且与神经退行性变性有关。结论神经毒性和细胞毒性的证据在与高能量需求细胞相关的选择性关系中趋同,这似乎是有助于理解这些协同效应的关键特征。长期暴露于醋原素可增强神经损伤,因此,建议适量饮用番荔枝科水果的浸剂、提取物和果肉。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Acetogenins from Annonaceae plants: potent antitumor and neurotoxic compounds

Background

Acetogenins are compounds found in Annonaceae, such as soursop (A. muricata) and pine cone (A. squamosa), and present cytotoxic properties, with antiproliferative and antitumor effects. However, they have also been implicated in the neurotoxic effects that are associated with atypical Parkinsonism. This study aimed to perform a systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.

Methods

This study aimed to perform a systematic review and identify the cytotoxic and selective mechanisms for neoplastic cells and neurotoxic acetogenins.

Results

The antitumor mechanisms of action were through apoptotic actions, negative regulation of the tumor growth factor and genotoxicity. The evidenced neurotoxic mechanisms were via the inhibition of neuronal mitochondrial complex I and dysfunctions of the tau protein. Acetogenins demonstrated punctual and selective anti-cancer action, though its selectivity remains unclear, and effects associated with neurodegeneration.

Conclusion

The evidences of neurotoxicity and cytotoxicity converges in a selectivity relationship associated with cells that require high energy demand and this seems to be a key feature that can help to understand these synergistic effects. Chronic exposure to acetogenins can potentiate neural damage, thus, moderate consumption of infusions, extracts and pulp of Annonaceae fruits is recommended.

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来源期刊
PharmaNutrition
PharmaNutrition Agricultural and Biological Sciences-Food Science
CiteScore
5.70
自引率
3.10%
发文量
33
审稿时长
12 days
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