Fawad Ali , Sumama N. Kalva , Kamal H. Mroue , Kripa S. Keyan , Yongfeng Tong , Omar M. Khan , Muammer Koç
{"title":"Mg-Incorporated 3D打印PLA生物医学支架的降解评估","authors":"Fawad Ali , Sumama N. Kalva , Kamal H. Mroue , Kripa S. Keyan , Yongfeng Tong , Omar M. Khan , Muammer Koç","doi":"10.1016/j.bprint.2023.e00302","DOIUrl":null,"url":null,"abstract":"<div><p>Polylactic acid (PLA)/Magnesium (Mg)-based composites exhibit great potential for applications in bone regeneration and tissue engineering. PLA is a biodegradable and biocompatible polymer, that has the ability to be easily shaped into diverse structures like scaffolds, films, and fibers. However, its inherent low biodegradability limits its applicability for tissue engineering. On the other hand, magnesium, a biocompatible metal known for its good biodegradability and osteoconductivity, is well-suited for bone tissue engineering. In this study, we fabricated and characterized a composite material of Mg/PLA with 5, 10, and 15 wt%Mg alloy (AZ61), which was subsequently 3D printed. The incorporation of Mg particles into PLA matrix offers a solution to overcome the low biodegradation limitations typically associated with the PLA. Moreover, it helps counteract the negative consequences related to the rapid degradation of Mg, such as alkalinization and excessive release of H<sub>2</sub>. Additionally, the change in pH values and changes in mass during <em>in vitro</em> degradation indicated that the addition of Mg effectively counteracted the acidic byproducts generated by PLA. Furthermore, X-Ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) spectroscopy were utilized to investigate the degradation of the scaffolds, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare and contrast the thermal properties of the composites. Our findings demonstrate that the addition of Mg significantly influences the thermal properties of PLA and notably accelerates its degradation, in addition to its noticeable influence on cell adhesion.</p></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Degradation assessment of Mg-Incorporated 3D printed PLA scaffolds for biomedical applications\",\"authors\":\"Fawad Ali , Sumama N. Kalva , Kamal H. Mroue , Kripa S. Keyan , Yongfeng Tong , Omar M. Khan , Muammer Koç\",\"doi\":\"10.1016/j.bprint.2023.e00302\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Polylactic acid (PLA)/Magnesium (Mg)-based composites exhibit great potential for applications in bone regeneration and tissue engineering. PLA is a biodegradable and biocompatible polymer, that has the ability to be easily shaped into diverse structures like scaffolds, films, and fibers. However, its inherent low biodegradability limits its applicability for tissue engineering. On the other hand, magnesium, a biocompatible metal known for its good biodegradability and osteoconductivity, is well-suited for bone tissue engineering. In this study, we fabricated and characterized a composite material of Mg/PLA with 5, 10, and 15 wt%Mg alloy (AZ61), which was subsequently 3D printed. The incorporation of Mg particles into PLA matrix offers a solution to overcome the low biodegradation limitations typically associated with the PLA. Moreover, it helps counteract the negative consequences related to the rapid degradation of Mg, such as alkalinization and excessive release of H<sub>2</sub>. Additionally, the change in pH values and changes in mass during <em>in vitro</em> degradation indicated that the addition of Mg effectively counteracted the acidic byproducts generated by PLA. Furthermore, X-Ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) spectroscopy were utilized to investigate the degradation of the scaffolds, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare and contrast the thermal properties of the composites. Our findings demonstrate that the addition of Mg significantly influences the thermal properties of PLA and notably accelerates its degradation, in addition to its noticeable influence on cell adhesion.</p></div>\",\"PeriodicalId\":37770,\"journal\":{\"name\":\"Bioprinting\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-08-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioprinting\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2405886623000453\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Computer Science\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886623000453","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}
Degradation assessment of Mg-Incorporated 3D printed PLA scaffolds for biomedical applications
Polylactic acid (PLA)/Magnesium (Mg)-based composites exhibit great potential for applications in bone regeneration and tissue engineering. PLA is a biodegradable and biocompatible polymer, that has the ability to be easily shaped into diverse structures like scaffolds, films, and fibers. However, its inherent low biodegradability limits its applicability for tissue engineering. On the other hand, magnesium, a biocompatible metal known for its good biodegradability and osteoconductivity, is well-suited for bone tissue engineering. In this study, we fabricated and characterized a composite material of Mg/PLA with 5, 10, and 15 wt%Mg alloy (AZ61), which was subsequently 3D printed. The incorporation of Mg particles into PLA matrix offers a solution to overcome the low biodegradation limitations typically associated with the PLA. Moreover, it helps counteract the negative consequences related to the rapid degradation of Mg, such as alkalinization and excessive release of H2. Additionally, the change in pH values and changes in mass during in vitro degradation indicated that the addition of Mg effectively counteracted the acidic byproducts generated by PLA. Furthermore, X-Ray photoelectron spectroscopy (XPS) and Fourier transform infrared (FT-IR) spectroscopy were utilized to investigate the degradation of the scaffolds, while thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare and contrast the thermal properties of the composites. Our findings demonstrate that the addition of Mg significantly influences the thermal properties of PLA and notably accelerates its degradation, in addition to its noticeable influence on cell adhesion.
期刊介绍:
Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.