生物制剂与小分子&作用机制

IF 0.4 Q4 SURGERY

Seminars in Colon and Rectal Surgery Pub Date : 2022-03-01 DOI:10.1016/j.scrs.2022.100861

Katherine Falloon MD , Ruthvik Padival MD , Satya Kurada MD , Sara El Ouali MD , Florian Rieder MD

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引用次数: 0

摘要

炎症性肠病是一组慢性、反复发作的胃肠道疾病。最初有限的治疗选择随着生物制剂和小分子的出现而显著扩大。生物制剂和小分子根据其免疫靶点可分为抗肿瘤坏死因子、抗白细胞介素、抗整合素和janus激酶途径抑制剂四类。每一类药物都通过特定的作用机制发挥作用，这决定了它的使用适应症、有效性和安全性。

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Biologic agents and small molecules – mechanism of action

Inflammatory bowel diseases are a group of chronic, relapsing disorders of the gastrointestinal tract. The initially limited therapy options were significantly expanded with the advent of biologics and small molecules. Biologics and small molecules can be divided into four categories based on their immunologic targets – anti-tumor necrosis factor, anti-interleukin, anti-integrin, and janus kinase pathway inhibitor. Each class of medication functions through a particular mechanism of action that dictates its indications for use, rate of efficacy, and safety profile.

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来源期刊

Seminars in Colon and Rectal Surgery SURGERY-

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： Seminars in Colon and Rectal Surgery offers a comprehensive and coordinated review of a single, timely topic related to the diagnosis and treatment of proctologic diseases. Each issue is an organized compendium of practical information that serves as a lasting reference for colorectal surgeons, general surgeons, surgeons in training and their colleagues in medicine with an interest in colorectal disorders.