口服和局部伊维菌素联合治疗疥疮患者的疗效比较

Q4 Pharmacology, Toxicology and Pharmaceutics
Zubaidah A Al-Asadi, Khalil I. Al-Hamdi, J. Ahmed
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引用次数: 0

摘要

背景:疥疮是一种常见的寄生性皮肤病,主要通过皮肤直接接触传播。氯菊酯被认为是标准的处理方法;然而,由于对氯氰菊酯的耐药性增加,最近的研究调查了其他局部制剂如伊维菌素作为替代治疗的效果。本研究的目的:与氯氰菊酯相比,本研究旨在评估伊维菌素单独外用或与口服伊维菌素联合使用对疥疮病变的有效性和安全性。患者和方法:236例无并发症的疥疮患者参与了本研究。研究人群被随机分为三组。第一组接受氯氰菊酯,第二组接受局部伊维菌素,第三组接受局部和口服伊维菌素的组合。每位患者间隔一周接受两次注射。对患者进行了第一、第二和第四周的随访。结果:在第一周,接受联合治疗的组瘙痒的严重程度和病变的数量都显著减少,减少百分比分别为(77.6,53.9%),而局部伊维菌素组为(61.8,55.2%),氯氰菊酯组为(8.3,19%)。在第4周,联合治疗组中15.8%的患者报告严重瘙痒,显著低于其他组的相应值。结论:外用和口服伊维菌素比单独外用伊维菌素或氯氰菊酯安全有效。它在第一周就取得了显著的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Eff ectiveness of Combined Oral and Topical Ivermectin Compared to Topical Treatments in Patients with Scabies
Background: Scabies is a common parasitic skin infestation transmitted mainly through direct skin contact. Permethrin was considered the standard treatment; however, due to increasing resistance against permethrin, recent research investigates the eff ect of other topical preparations like ivermectin as an alternative treatment. Aim of the study: This study aim to evaluate the effi cacy and safety of ivermectin whether its topical alone or combined with oral form of ivermectin in the same time on scabietic lesions compared to permethrin. Patient and method: 236 patients with uncomplicated scabies participated in the study. The study population was selected and divided randomly into three groups. The fi rst group received permethrin, the second group received topical ivermectin, and the third group received a combination of topical and oral ivermectin. Each patient received two doses one week apart. The patients were followed up for the fi rst, second, and fourth week of treatment. Results: At the fi rst week, the group who received the combination of treatments has a signifi cant decrease in both severity of itching and number of lesions, the reduction percentage is (77.6, 53.9%), respectively compared to (61.8, 55.2%) with topical ivermectin and ( 8.3, 19% ) with permethrin. At the 4th week, 15.8% of patients in the combination treatment group reported severe itching, signifi cantly lower than the corresponding values in the other groups. Conclusion: The combination of topical and oral ivermectin is safe and more eff ective than topical ivermectin or permethrin alone. It achieves a remarkable eff ect in the fi rst week.
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来源期刊
International Journal of Drug Delivery Technology
International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
0.70
自引率
0.00%
发文量
0
期刊介绍: International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.
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