Annotated Review on Various Biological Activities of Quinoline Molecule

Quinoline or Benzopyridine moiety remained an attraction among researchers in the 21st century. Quinoline is a heterocyclic aromatic organic compound with the chemical formula C9H7N. This moiety is considered a biologically important active source that possesses all types of medicinal potentials due to its simple chemistry, ease of synthesis, and a wide variety of numerous biological potentials in both natural and synthetic derivatives such as antimalarial, antibacterial, anti-inflammatory, anti-arrhythmic, anti-anginal, antihypertensive, anti-depressant, anti-convulsant. This pharmacological diversity of quinoline has attracted researchers to explore this moiety by making modifications at various possible positions. In the present review, we are outlining the potential of quinoline as an antimalarial, anticancer, anti-inflammatory, and antibacterial agent. Furthermore, by attaining the knowledge of molecular targets, structural insights, and SARs, this review may be supportive for medicinal chemists to design more potent, safe, selective, and cost-effective quinoline derivatives for various biological properties.