{"title":"基于纳米材料的表面等离子体共振传感芯片检测皮肤和乳腺癌症","authors":"Vikash Kumar, Sanjeev Kumar Raghuwanshi, Santosh Kumar","doi":"10.1007/s11468-023-02022-5","DOIUrl":null,"url":null,"abstract":"<div><p>Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO<sub>3</sub>, and 2D layering of materials (MoSe<sub>2</sub>/WS<sub>2</sub>) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS<sub>2</sub> (each of 0.5 nm) and two layers of BaTiO<sub>3</sub> (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU<sup>−1</sup>), 0.576 (degree<sup>−1</sup>), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU<sup>−1</sup>), 0.829 (degree<sup>−1</sup>), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.</p></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"19 2","pages":"643 - 654"},"PeriodicalIF":3.3000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer\",\"authors\":\"Vikash Kumar, Sanjeev Kumar Raghuwanshi, Santosh Kumar\",\"doi\":\"10.1007/s11468-023-02022-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO<sub>3</sub>, and 2D layering of materials (MoSe<sub>2</sub>/WS<sub>2</sub>) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS<sub>2</sub> (each of 0.5 nm) and two layers of BaTiO<sub>3</sub> (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU<sup>−1</sup>), 0.576 (degree<sup>−1</sup>), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU<sup>−1</sup>), 0.829 (degree<sup>−1</sup>), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.</p></div>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"19 2\",\"pages\":\"643 - 654\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11468-023-02022-5\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s11468-023-02022-5","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Nanomaterial-Based Surface Plasmon Resonance Sensing Chip for Detection of Skin and Breast Cancer
Today’s advancements in technology in modern-day life have substantially raised the significance of surface plasmon resonance (SPR) sensors. In order to enhance the sensor’s performance, experts are now focused on developing a SPR biomedical sensor that integrates a prism with a thin nanocomposite layer. The proposed SPR biosensor has been built with silver, BaTiO3, and 2D layering of materials (MoSe2/WS2) for the purpose to identifying skin and breast cancer cells. In this analysis, the attenuated total reflection (ATR) technique of SPR is used for the detection of skin cancer (basal cell) and breast cancer cells (MM-231 and MCF-7) to evaluate the results. It is being observed that by utilizing two metallic silver coatings with a thickness of 50 nm and 10 nm. The effectiveness of the device can be improved with two layers of WS2 (each of 0.5 nm) and two layers of BaTiO3 (each of 5 nm); the highest sensitivity can be achieved in the case of skin cancer. The numerical findings show that the basal cell’s highest sensitivity is 253.5 (°/RIU) and breast (MM-231 and MCF-7) cancer cells are 309.2857°/RIU and 295.71°/RIU. The figure of merit (FoM), detection accuracy (DA), and signal-to-noise ratio (SNR) are 146.11 (RIU−1), 0.576 (degree−1), and 2.922, respectively, for basal cells, and for breast cancer, 255.66 (RIU−1), 0.829 (degree−1), and 3.59 are realized. Lastly, the numerical outcomes derived in this manuscript revealed a high degree of sensitivity and FoM compared to those of previous research studies.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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