A rare case of extraskeletal Ewing’s sarcoma arising from the larynx

Abstract We report a rare case of extraskeletal Ewing’s sarcoma originating from the larynx. This report describes a 20-year-old man with a large laryngeal tumor extending to the left hypopharynx. This was confirmed to be Ewing’s sarcoma based on biopsy and fluorescence in situ hybridization (FISH) findings. Surgery was considered to be inappropriate due to the large tumor size. He received one course of VDC-IE (vincristine, doxorubicin, cyclophosphamide, ifosfamide, and etoposide) chemotherapy, but this proved to be ineffective. Radiotherapy at a total dose of 68.4 Gy/38 fractions resulted in marked shrinkage of the tumor. The patient is alive 20 months after treatment with no sign of recurrence or metastasis. The highlights of this report are that FISH is important for the early confirmation of a suspected Ewing’s sarcoma diagnosis and that the treatment provided is effective for prolonging the survival of a patient with Ewing’s sarcoma.