用Nernst–Planck方程、cable模型和纯扩散模型研究一维枝晶中钙诱导钙释放的微分行为

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2024-06-01 Epub Date: 2023-04-06 DOI:10.1007/s11571-023-09952-0
Yinyun Li
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引用次数: 0

摘要

钙的来源和动态是调节树突整合的关键因素。除了电压门控和配体门控钙离子流入外,钙的一个重要来源是内质网内部储存的钙离子,其再生过程是钙诱导钙释放(CICR)。要触发这一过程,肌醇 1,4,5-三磷酸(IP3)和钙需要满足一定的要求。我们的论文旨在研究 CICR 如何取决于膜电位的动态。我们利用一维树突模型,通过内斯特-普朗克方程(NPE)、电缆模型和纯扩散(PD)模型计算膜电位,通过计算模拟突触刺激注入的钙离子流,预测随后的 CICR 和钙波传播。结果表明,NPE 和电缆模型的电扩散过程在 CICR 启动和钙波传播方面存在很大差异。我们发现,与 NPE 相比,电缆模型触发 CICR 的 IP3 刺激阈值更低,但钙波传播更困难;与 NPE 相比,PD 模型启动 CICR 过程所需的 IP3 阈值更高,且钙波持续时间更短;与电缆模型和 PD 模型相比,NPE 的再生钙波传播速度更快。我们的研究探讨了带电离子的电扩散动力学在树突结构中调节 CICR 过程的重要作用,并为下游信号传导过程需要持续钙离子的神经过程提供了理论预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Differential behaviors of calcium-induced calcium release in one dimensional dendrite by Nernst-Planck equation, cable model and pure diffusion model.

The source and dynamics of calcium is the key factor that regulates dendritic integration. Apart from the voltage-gated and ligand-gated calcium influx, an important source of calcium is from inner store of endoplasmic reticulum with a regenerative process of calcium-induced calcium release (CICR). To trigger this process, inositol 1,4,5-trisphosphate (IP3) and calcium are needed to satisfy certain requirements. The aim of our paper is to investigate how the CICR depends on the dynamics of membrane potential. We utilize one dimensional dendritic model to calculate membrane potential by Nernst-Planck Equation (NPE) and cable model and Pure Diffusion (PD) model, computational simulations are carried out to inject the calcium influx by synaptic stimulation and to predict subsequent CICR and calcium wave propagation. Our results demonstrate that CICR initiation and calcium wave propagation have much difference between electro-diffusion process of NPE and cable model. We find that cable model has lower threshold of IP3 stimulation to trigger CICR but is more difficult for calcium propagation than NPE, PD model requires even higher threshold of IP3 to initiate CICR process and calcium duration is shorter than NPE; the regenerative calcium wave propagates with faster speed in NPE than that in cable model and in PD model. Our work addresses the important role of electro-diffusion dynamics of charged ions in regulating CICR process in dendritic structure; and provides theoretical predictions for neurological process which requires sustaining calcium for downstream signaling processes.

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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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