Xiaoqing Li , Shikai Yan , Jihong Lu , Rui Wang , Xianpeng Ma , Xue Xiao , Yan Zhang , Huizi Jin
{"title":"两种具有心肌细胞保护作用的葱属新酚类胺","authors":"Xiaoqing Li , Shikai Yan , Jihong Lu , Rui Wang , Xianpeng Ma , Xue Xiao , Yan Zhang , Huizi Jin","doi":"10.1016/j.chmed.2022.12.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>To isolate the phenolic amides from the dried bulbs of <em>Allium chinense</em> and investigate their myocardium protective activities.</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated and purified by combining with silica gel column, Sephadex LH-20 column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells <em>in vitro</em>.</p></div><div><h3>Results</h3><p>Two new phenolic amides, namely, alichinemide I (<strong>1</strong>) and alichinemide II (<strong>2</strong>), and six konwn amides were isolated from the dried bulbs of <em>A. chinense</em>. The structures of compounds <strong>3</strong>–<strong>8</strong> were identified as 3-indolcarbaldehyde (<strong>3</strong>), 1-(2-aminophenyl)urea (<strong>4</strong>), 2,3,4,9-tetrahydro-1<em>H</em>-pyrido[3,4-b]indole-3-carboxylic acid (<strong>5</strong>), <em>N-trans</em>-feruloyltyramine (<strong>6</strong>), <em>N-trans-p</em>-coumaroyltyramine (<strong>7</strong>), and <em>N</em>-(3,4-dimethoxyphenethyl) acetamide (<strong>8</strong>). Compound <strong>3</strong> (50 μmol/L) showed significant inhibitory effect on the damage of H9c2 myocardial cells induced by H<sub>2</sub>O<sub>2</sub> <em>in vitro</em>.</p></div><div><h3>Conclusion</h3><p>Compounds <strong>1</strong> and <strong>2</strong> were new phenolic amides. Compound <strong>3</strong> could be one of the potential myocardium protective constituents of <em>A. chinense</em>.</p></div>","PeriodicalId":9916,"journal":{"name":"Chinese Herbal Medicines","volume":"15 4","pages":"Pages 603-606"},"PeriodicalIF":4.7000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S167463842300014X/pdfft?md5=08568a62f3d3a6fd04f5eacfdc892612&pid=1-s2.0-S167463842300014X-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Two new phenolic amides from Allium chinense\",\"authors\":\"Xiaoqing Li , Shikai Yan , Jihong Lu , Rui Wang , Xianpeng Ma , Xue Xiao , Yan Zhang , Huizi Jin\",\"doi\":\"10.1016/j.chmed.2022.12.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>To isolate the phenolic amides from the dried bulbs of <em>Allium chinense</em> and investigate their myocardium protective activities.</p></div><div><h3>Methods</h3><p>The chemical constituents were isolated and purified by combining with silica gel column, Sephadex LH-20 column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells <em>in vitro</em>.</p></div><div><h3>Results</h3><p>Two new phenolic amides, namely, alichinemide I (<strong>1</strong>) and alichinemide II (<strong>2</strong>), and six konwn amides were isolated from the dried bulbs of <em>A. chinense</em>. The structures of compounds <strong>3</strong>–<strong>8</strong> were identified as 3-indolcarbaldehyde (<strong>3</strong>), 1-(2-aminophenyl)urea (<strong>4</strong>), 2,3,4,9-tetrahydro-1<em>H</em>-pyrido[3,4-b]indole-3-carboxylic acid (<strong>5</strong>), <em>N-trans</em>-feruloyltyramine (<strong>6</strong>), <em>N-trans-p</em>-coumaroyltyramine (<strong>7</strong>), and <em>N</em>-(3,4-dimethoxyphenethyl) acetamide (<strong>8</strong>). Compound <strong>3</strong> (50 μmol/L) showed significant inhibitory effect on the damage of H9c2 myocardial cells induced by H<sub>2</sub>O<sub>2</sub> <em>in vitro</em>.</p></div><div><h3>Conclusion</h3><p>Compounds <strong>1</strong> and <strong>2</strong> were new phenolic amides. Compound <strong>3</strong> could be one of the potential myocardium protective constituents of <em>A. chinense</em>.</p></div>\",\"PeriodicalId\":9916,\"journal\":{\"name\":\"Chinese Herbal Medicines\",\"volume\":\"15 4\",\"pages\":\"Pages 603-606\"},\"PeriodicalIF\":4.7000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S167463842300014X/pdfft?md5=08568a62f3d3a6fd04f5eacfdc892612&pid=1-s2.0-S167463842300014X-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chinese Herbal Medicines\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S167463842300014X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chinese Herbal Medicines","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S167463842300014X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
To isolate the phenolic amides from the dried bulbs of Allium chinense and investigate their myocardium protective activities.
Methods
The chemical constituents were isolated and purified by combining with silica gel column, Sephadex LH-20 column, HPLC and other chromatography techniques. Their structures were elucidated by NMR techniques and mass spectrometry. The isolated compounds were evaluated to determine their protective effect for myocardium cells in vitro.
Results
Two new phenolic amides, namely, alichinemide I (1) and alichinemide II (2), and six konwn amides were isolated from the dried bulbs of A. chinense. The structures of compounds 3–8 were identified as 3-indolcarbaldehyde (3), 1-(2-aminophenyl)urea (4), 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (5), N-trans-feruloyltyramine (6), N-trans-p-coumaroyltyramine (7), and N-(3,4-dimethoxyphenethyl) acetamide (8). Compound 3 (50 μmol/L) showed significant inhibitory effect on the damage of H9c2 myocardial cells induced by H2O2in vitro.
Conclusion
Compounds 1 and 2 were new phenolic amides. Compound 3 could be one of the potential myocardium protective constituents of A. chinense.
期刊介绍：
Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included.
CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.
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