奶碱综合征与他克莫司代谢

Q4 Medicine
Gurbir Singh , Sabrina Lee , Meena Parakaal , Michelle Hwang , Erik L. Lum
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引用次数: 0

摘要

慢性免疫抑制治疗对所有移植患者至关重要,有助于预防排斥反应、慢性损伤和同种异体移植物丧失。他克莫司用于90%以上的肾移植受者的免疫抑制,需要药物水平监测。众所周知,许多处方药可以改变他克莫司的代谢,导致不可预测的水平,可能使患者暴露于上述并发症。然而,非处方药的使用经常被忽视。在这里,我们提出了一个病例报告,其中非处方碳酸钙显著影响患者的他克莫司代谢导致不可预测的水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Milk-alkali syndrome and tacrolimus metabolism

Chronic immunosuppressive therapy is critical to all transplant patients to help prevent rejection, chronic injury and loss of allograft. Tacrolimus is used as immunosuppression in more than ninety percent of kidney transplant recipients, and requires drug level monitoring. It is known that many prescribed medications can alter tacrolimus metabolism and lead to unpredictable levels that may expose patients to the above-mentioned complications. However, the use of over-the-counter medications is often overlooked. Here, we present a case report in which over-the-counter calcium carbonate significantly affected the patient's tacrolimus metabolism leading to unpredictable levels.

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来源期刊
Transplantation Reports
Transplantation Reports Medicine-Transplantation
CiteScore
0.60
自引率
0.00%
发文量
24
审稿时长
101 days
期刊介绍: To provide to national and regional audiences experiences unique to them or confirming of broader concepts originating in large controlled trials. All aspects of organ, tissue and cell transplantation clinically and experimentally. Transplantation Reports will provide in-depth representation of emerging preclinical, impactful and clinical experiences. -Original basic or clinical science articles that represent initial limited experiences as preliminary reports. -Clinical trials of therapies previously well documented in large trials but now tested in limited, special, ethnic or clinically unique patient populations. -Case studies that confirm prior reports but have occurred in patients displaying unique clinical characteristics such as ethnicities or rarely associated co-morbidities. Transplantation Reports offers these benefits: -Fast and fair peer review -Rapid, article-based publication -Unrivalled visibility and exposure for your research -Immediate, free and permanent access to your paper on Science Direct -Immediately citable using the article DOI
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