天然来源的胰脂肪酶抑制剂的综述:肥胖的潜在靶点

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2021-01-21 DOI:10.2174/1573408017666210121114441

B. T., M. R, Suriyaprakash Tnk, S. N.

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引用次数: 4

摘要

肥胖是一种世界性的生活方式障碍，其发病率正在以惊人的速度增长。胰脂肪酶（PL）在脂质代谢中起着关键作用，因此是肥胖治疗的潜在靶点。有报道称，许多来自天然来源的生物活性化合物是PL抑制剂的巨大库。在寻找天然胰脂肪酶抑制剂方面，综述了天然产物抑制胰脂肪酶活性的潜力。在这篇综述中，对从各种电子数据库和期刊文章出版物的文献检索中获得的数据进行了综述。本文对61种生物来源的胰脂肪酶抑制活性进行了综述，并得到了体内外临床前实验证据的支持。本文可作为植物、海洋和昆虫衍生的具有PL抑制活性的天然产物中的治疗性铅分子的现成参考。这项研究更侧重于发现更巧妙的胰脂肪酶抑制剂，其后果较小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A review on pancreatic lipase inhibitors from natural sources: a potential target for obesity

Obesity is a worldwide lifestyle disorder and its incidence is growing at an alarming rate. Pancreatic lipase (PL) plays a key role in lipid metabolism and hence a potential target for obesity treatment. There have been reports that many bioactive compounds from natural sources are vast pool of PL inhibitors. In search of natural pancreatic lipase inhibitors, the review summarizes the potential of natural products for their pancreatic lipase inhibitory activity. In this review the data obtained from literature search across various electronic databases and journal article publications are reviewed. The pancreatic lipase inhibitory activities of 61 biological sources were reviewed in this paper is backed by preclinical experimental evidence, either in vivo or in vitro. This article can be used as a ready to use reference for therapeutic lead molecules from plants, marine and insect derived natural products with PL inhibitory activity. The research is more focused on the discovery of more ingenious pancreatic lipase inhibitors with lesser consequences.

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.