脱水羊膜异体移植在晚期糖尿病足溃疡中的应用:1例报告及文献复习

Pub Date : 2022-07-20 DOI:10.3390/reports5030028
Catherine Becker, M. Regulski, Scott A. Martin, T. Barrett
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引用次数: 0

摘要

糖尿病足溃疡(DFUs)的管理提出了挑战,即使是最有经验的伤口护理提供者。由于许多dfu具有慢性、不愈合的性质,因此在这种疾病的治疗和护理方面取得进展尤为重要。本病例研究旨在报告脱水羊膜异体移植(DAMA)治疗糖尿病足溃疡的疗效。本研究的患者是一名44岁男性,右脚出现侵袭性感染,导致开放性伤口持续18个月。该患者在七周内每周接受双层DAMA应用。经首次应用检查,伤口被分类为Wagner 3级,伴有下层肌肉坏死。在最后一次检查时,伤口完全闭合。所显示的结果包括伤口的大小、深度、边缘、坏死组织的数量和上皮的改善。本案例研究表明,DAMA的应用有可能增强人体的自然DFU愈合反应;然而,未来的非随机和随机对照试验需要进一步确定其有效性。
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Application of Dehydrated Amniotic Membrane Allografts in Advanced Diabetic Foot Ulceration: Case Report and Review of Literature
The management of diabetic foot ulcers (DFUs) presents challenges to even the most experienced wound-care providers. Because of the chronic, non-healing nature of many DFUs, advances in the treatment and care of this disease process are particularly relevant. This case study aims to report the efficacy of the application of dehydrated amniotic membrane allograft (DAMA) to a diabetic foot ulcer. The patient in this study is a 44-year-old male who presented with an aggressive infection on his right foot, which resulted in an open wound of 18-month duration. This patient received weekly applications of dual-layer DAMA over seven weeks. Upon examination at the initial application, the wound was classified as a Wagner grade 3 with necrosis of the underlying muscle. Upon inspection at the final visit, the wound was closed entirely. The results that were shown include improvements in the size, depth, edges, necrotic tissue amount, and epithelization of the wound. This case study demonstrates that the application of DAMA has the potential to augment the body’s natural DFU healing response; however, future nonrandomized and randomized controlled trials are needed to establish its efficacy further.
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