骨和关节感染的微生物学特征和耐药性:伊朗德黑兰一家大型转诊医院骨科病房的调查

IF 0.5 4区 医学 Q4 MICROBIOLOGY
Samaneh Salarvand, A. Abdollahi, Masoumeh Doraghi, Seyed Amir Miratashi Yazdi, Z. Panahi, S. Mortazavi, E. Nazar
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引用次数: 0

摘要

背景:接受骨科手术的患者存在院内感染的风险,已知抗生素耐药性会增加此类感染的风险。目的:我们的目的是确定在伊朗最大的转诊医院之一骨科病房住院的患者的抗生素耐药率。我们还确定了骨和关节感染患者的抗生素耐药微生物。方法:本横断面调查于2018年3月至2022年3月期间在德黑兰一家大型转诊医院完成。通过审查医院信息系统收集实验室数据,包括分离的微生物及其抗生素耐药性模式。结果:共收集疑似细菌感染患者标本2650份,其中细菌感染阳性880份(33.2%)。其中,金黄色葡萄球菌(红霉素)最高耐药率为58%,肺炎克雷伯菌(氨苄青霉素/舒巴坦)最高耐药率为75%,大肠杆菌(亚胺培南)最高耐药率为64.5%,凝固酶阴性葡萄球菌(万古霉素)最高耐药率为76.2%,鲍曼不动杆菌(亚胺培南)最高耐药率为100%,表皮葡萄球菌(红霉素)最高耐药率为52%,肠杆菌(庆大霉素)最高耐药率为85.9%,铜绿假单胞菌(氨苄青霉素/舒巴坦)最高耐药率为65.6%。总耐多药率为27.6%。结论:骨科病房各菌株对常用抗生素的耐药率较高,尤其是红霉素、氨苄西林、亚胺培南、万古霉素、庆大霉素。此外,在这些病房中,多种抗生素耐药率很高,其中超过四分之一的细菌菌株表现出这种耐药。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microbiological Profile and Drug Resistance in Bone and Joint Infections: A Survey in Orthopedic Wards of a Great Referral Hospital in Tehran, Iran
Background: Patients undergoing orthopedic surgery are at risk of nosocomial infections, and antibiotic resistance is known to increase the risk of such infections. Objectives: We aimed to determine the rate of antibiotic resistance in patients admitted to orthopedic wards in one of the largest referral hospitals in Iran. We also ascertained responsible antibiotic-resistant microorganisms in patients with bone and joint infections. Methods: The present cross-sectional investigation was concluded over a period of five years, from March 2018 to March 2022, at a great referral hospital in Tehran. Laboratory data, including the organisms isolated and their antibiotic resistance patterns, were collected by reviewing the hospital information system. Results: In total, 2650 specimens obtained from patients with suspected bacterial infections were transferred to the hospital’s laboratory, 880 (33.2%) of which were positive for bacterial infections. The maximum antibiotic resistance rate against an antibiotic was observed to be 58% for Staphylococcus aureus (erythromycin), 75% for Klebsiella pneumonia (ampicillin/sulbactam), 64.5% for Escherichia coli (imipenem), 76.2% for coagulase-negative Staphylococcus (vancomycin), 100% for Acinetobacter baumannii (imipenem), 52% for S. epidermidis (erythromycin), 85.9% for Enterobacter species (gentamycin), and 65.6% for Pseudomonas aeruginosa (ampicillin/sulbactam). The overall rate of multi-drug resistance was obtained as 27.6%. Conclusions: A high rate of resistance of various bacterial strains to common antibiotics, especially erythromycin, ampicillin, imipenem, vancomycin, and gentamycin, was denoted in orthopedic wards. Also, a high rate of multi-antibiotic resistance was encountered in these wards, where more than a quarter of the bacterial strains showed such resistance.
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
56
审稿时长
6-12 weeks
期刊介绍: Jundishapur Journal of Microbiology, (JJM) is the official scientific Monthly publication of Ahvaz Jundishapur University of Medical Sciences. JJM is dedicated to the publication of manuscripts on topics concerning all aspects of microbiology. The topics include medical, veterinary and environmental microbiology, molecular investigations and infectious diseases. Aspects of immunology and epidemiology of infectious diseases are also considered.
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