LFER在五元氮杂环体系N(1)-H酸中的应用——研究生化学教学作业述评

Current physical chemistry Pub Date : 2022-06-24 DOI:10.2174/1877946812666220624125226

S. Rachuru, Jagannadham Vandanapu

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引用次数: 0

摘要

本实验室首次尝试将Hammett和Taft方程应用于五元杂环系吡咯、吡唑、咪唑和三唑。结果表明，3- x -吡咯、3- x -吡唑、4- x -吡唑、4- x -咪唑、3- x -1,2,4-三唑和4- x -1,2,3-三唑的N(1)-H酸的pKa值与Hammett值具有良好的相关性。

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Application of LFER to the N(1)-H Acidities of Five Membered Nitrogen Heterocyclic Ring Systems: A Review on Graduate Chemical Education Exercise

An attempt is made for the first time in our laboratory to apply the Hammett and Taft equations to the five-membered heterocyclic ring systems pyrroles, pyrazoles, imidazole, and triazoles. It is shown that the pKa values of N(1)-H acidities of 3-X-pyrroles, 3-X-pyrazole, 4-X-pyrazole, 4-X-imidazole, 3-X-1,2,4-triazole and 4-X-1,2,3-triazole correlated well with Hammett  values.

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Current physical chemistry

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