Lokendra Singh, Abdulkarem H. M. Almawgani, Yesudasu Vasimalla, Roshan Kumar, Turki Alsuwian
{"title":"基于SPR的无标记传感器用于基于RI的尿素浓度检测","authors":"Lokendra Singh, Abdulkarem H. M. Almawgani, Yesudasu Vasimalla, Roshan Kumar, Turki Alsuwian","doi":"10.1007/s11468-023-01956-0","DOIUrl":null,"url":null,"abstract":"<div><p>The real-time, label-free, and high sensitivity are the inherent advantages of surface plasmon resonance (SPR) technology, making it the most versatile tool for sensing the street. It has been extensively used in various fields such as healthcare, management of the environment, and food-borne diseases. In the last several decades, kidney-related issues become more serious and resulting in physical degeneration and even death. The glomerular filtration rate (GFR) defines the functioning of the kidney concerning blood filtration. The GFR rate gets degraded with the increase in urea concentration in human bodies. Therefore, this study presents a highly sensitive gold nanoparticle SPR sensor based on an angular interrogation method for the enzymatic detection of urea samples. The biocompatibility of the sensor is enhanced by functionalizing the sensor with layers of molybdenum disulfide (MoS<sub>2</sub>) and cerium oxide (CeO<sub>2</sub>). Exposing the sensor to analytes without any biocompatible layer achieves a maximum sensitivity of 186.50°/RIU. On the other hand, a maximum sensitivity of 217.50°/RIU and 275°/RIU is attained for Au/MoS<sub>2</sub>/urease and Au/CeO<sub>2</sub>/urease combinations, respectively.</p></div>","PeriodicalId":736,"journal":{"name":"Plasmonics","volume":"18 6","pages":"2385 - 2392"},"PeriodicalIF":3.3000,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"SPR-Based Label-Free Sensor for RI-Based Detection of Urea Concentration\",\"authors\":\"Lokendra Singh, Abdulkarem H. M. Almawgani, Yesudasu Vasimalla, Roshan Kumar, Turki Alsuwian\",\"doi\":\"10.1007/s11468-023-01956-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The real-time, label-free, and high sensitivity are the inherent advantages of surface plasmon resonance (SPR) technology, making it the most versatile tool for sensing the street. It has been extensively used in various fields such as healthcare, management of the environment, and food-borne diseases. In the last several decades, kidney-related issues become more serious and resulting in physical degeneration and even death. The glomerular filtration rate (GFR) defines the functioning of the kidney concerning blood filtration. The GFR rate gets degraded with the increase in urea concentration in human bodies. Therefore, this study presents a highly sensitive gold nanoparticle SPR sensor based on an angular interrogation method for the enzymatic detection of urea samples. The biocompatibility of the sensor is enhanced by functionalizing the sensor with layers of molybdenum disulfide (MoS<sub>2</sub>) and cerium oxide (CeO<sub>2</sub>). Exposing the sensor to analytes without any biocompatible layer achieves a maximum sensitivity of 186.50°/RIU. On the other hand, a maximum sensitivity of 217.50°/RIU and 275°/RIU is attained for Au/MoS<sub>2</sub>/urease and Au/CeO<sub>2</sub>/urease combinations, respectively.</p></div>\",\"PeriodicalId\":736,\"journal\":{\"name\":\"Plasmonics\",\"volume\":\"18 6\",\"pages\":\"2385 - 2392\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2023-07-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Plasmonics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11468-023-01956-0\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plasmonics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s11468-023-01956-0","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
SPR-Based Label-Free Sensor for RI-Based Detection of Urea Concentration
The real-time, label-free, and high sensitivity are the inherent advantages of surface plasmon resonance (SPR) technology, making it the most versatile tool for sensing the street. It has been extensively used in various fields such as healthcare, management of the environment, and food-borne diseases. In the last several decades, kidney-related issues become more serious and resulting in physical degeneration and even death. The glomerular filtration rate (GFR) defines the functioning of the kidney concerning blood filtration. The GFR rate gets degraded with the increase in urea concentration in human bodies. Therefore, this study presents a highly sensitive gold nanoparticle SPR sensor based on an angular interrogation method for the enzymatic detection of urea samples. The biocompatibility of the sensor is enhanced by functionalizing the sensor with layers of molybdenum disulfide (MoS2) and cerium oxide (CeO2). Exposing the sensor to analytes without any biocompatible layer achieves a maximum sensitivity of 186.50°/RIU. On the other hand, a maximum sensitivity of 217.50°/RIU and 275°/RIU is attained for Au/MoS2/urease and Au/CeO2/urease combinations, respectively.
期刊介绍：
Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons.
Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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