甲型流感病毒亚群及其在发病机制和疫苗开发中的意义。

IF 8.7 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Annual Review of Animal Biosciences Pub Date : 2020-02-15 DOI:10.1146/annurev-animal-021419-083756

A. Ghorbani, J. Ngunjiri, Chang-won Lee

{"title":"甲型流感病毒亚群及其在发病机制和疫苗开发中的意义。","authors":"A. Ghorbani, J. Ngunjiri, Chang-won Lee","doi":"10.1146/annurev-animal-021419-083756","DOIUrl":null,"url":null,"abstract":"The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described \"incomplete\" virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 8 is February 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.","PeriodicalId":48953,"journal":{"name":"Annual Review of Animal Biosciences","volume":"1 1","pages":""},"PeriodicalIF":8.7000,"publicationDate":"2020-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1146/annurev-animal-021419-083756","citationCount":"7","resultStr":"{\"title\":\"Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development.\",\"authors\":\"A. Ghorbani, J. Ngunjiri, Chang-won Lee\",\"doi\":\"10.1146/annurev-animal-021419-083756\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described \\\"incomplete\\\" virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 8 is February 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.\",\"PeriodicalId\":48953,\"journal\":{\"name\":\"Annual Review of Animal Biosciences\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":8.7000,\"publicationDate\":\"2020-02-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1146/annurev-animal-021419-083756\",\"citationCount\":\"7\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annual Review of Animal Biosciences\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1146/annurev-animal-021419-083756\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"AGRICULTURE, DAIRY & ANIMAL SCIENCE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual Review of Animal Biosciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1146/annurev-animal-021419-083756","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, DAIRY & ANIMAL SCIENCE","Score":null,"Total":0}

引用次数: 7

摘要

甲型流感病毒（IAV）亚群的概念出现在大约75年前，当时Preben von Magnus描述了干扰传染性病毒复制的“不完整”病毒颗粒。现在人们普遍认为，传染性颗粒只占生物活性IAV亚群的一小部分。IAV准物种是一个极其多样化的生物和遗传异质粒子亚群，它们共同影响病毒的进化适应性。本文综述了IAV亚群的生物学和基因组多样性。它还讨论了IAV亚群在病毒发病机制和减毒活流感疫苗开发中的潜在作用。《动物生物科学年度评论》第8卷预计最终在线出版日期为2020年2月15日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development.

The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described "incomplete" virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 8 is February 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annual Review of Animal Biosciences BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ZOOLOGY

CiteScore

21.30

自引率

0.80%

发文量

期刊介绍： The Annual Review of Animal Biosciences is primarily dedicated to the fields of biotechnology, genetics, genomics, and breeding, with a special focus on veterinary medicine. This includes veterinary pathobiology, infectious diseases and vaccine development, and conservation and zoo biology. The publication aims to address the needs of scientists studying both wild and domesticated animal species, veterinarians, conservation biologists, and geneticists.