干细胞在治疗新冠肺炎相关器官损伤中的作用评估

E. Bryant, V. Gallicchio
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摘要

COVID-19是一种可在宿主中产生危及生命的并发症的疾病。它是由SARS-CoV-2冠状病毒引起的。这项工作检查和比较了涉及干细胞在研究和治疗COVID-19症状中的使用的现有出版物。具体来说,人造血干细胞服务于以研究为中心的目的,因为它们被纳入确定COVID-19的病理生理学;而骨髓间充质干细胞注射正被开发为医学治疗方法。人类造血干细胞已被用于形成人工类器官,这对于研究COVID-19对心血管、肺、肾、胃肠道和神经系统的影响至关重要。间充质干细胞再生组织并与宿主免疫系统沟通以诱导抗炎作用的能力使其成为将间充质干细胞溶液注射到covid -19感染患者体内的医学研究的关键。这些研究的结果虽然不完整,但表明MSCs能够缓解COVID-19症状。因此,造血干细胞和间充质干细胞都是
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation Of The Role Of Stem Cells In Treatments For Organ Damage Related To COVID-19
COVID-19 is an illness that can produce life-threatening complications in hosts. It is caused by the SARS-CoV-2 coronavirus. This work examines and compares existing publications covering the usage of stem cells in the research and treatment of COVID-19 symptoms. Specifically, hPSCs serve a purpose centered on research as they are incorporated into determining pathophysiology of COVID-19; whereas MSC injections are being developed as medical treatments. hPSCs have been utilized to form artificial organoids crucial to the study of COVID-19 effects on the cardiovascular, pulmonary, renal, gastrointestinal, and neural systems. The ability of MSCs to regenerate tissue and communicate with the host immune system to induce anti-inflammatory effects makes them key in medical studies during which MSC solutions are injected into COVID-19-infected patients. The results of these studies, though incomplete, show that MSCs are capable of alleviating COVID-19 symptoms. Both hPSCs and MSCs are therefore
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