Study the significance of serum immunoglobulin test in the diagnosis and treatment of hepatitis B

Objective To analyze the application value of serum immunoglobulin test in the diagnosis and treatment of hepatitis B. Methods 100 patients with chronic hepatitis B admitted to our hospital from January 2017 to January 2019 were selected as the study group, including 50 cases of mild hepatitis B and 50 cases of severe hepatitis B. And 50 cases of healthy subjects were selected as the control group in the same period. Serum IgG, IgA, and IgM levels were compared among all subjects, and serum total bilirubin (TBIL), prothrombin activity (PTA), and immunoglobulin were compared between the effective and ineffective patients in the study group. Results The serum IgG level of the severe chronic hepatitis B group was (15.72±2.83) g/L, the IgA level was (2.95±0.74) g/L, and the IgM level was (2.93±0.76) g/L, which were significantly higher than those of the mild chronic hepatitis B group (t=5.621 3, 6.781 2, 5.961 7, P<0.05). In the study group, 72 cases were effective and 28 cases were ineffective. The serum IgG level of the effective treatment group was (13.72±2.49) g/L, the IgA level was (2.54±0.43) g/L, and the IgM level was (2.48±0.39) g/L, PTA was (53.7±15.6)%, TBIL was (174.8±32.6) μmol/L, and there were statistically significant differences compared with the ineffective treatment group (t=4.713 8, 6.055 4, 11.240 4, 8.205 8, 25.506 0, P<0.05). Conclusion Serum immunoglobulin level can directly reflect the degree of hepatocyte damage in patients with hepatitis B, which provides an important basis for the diagnosis and treatment of clinical diseases. Key words: Hepatitis B; Diagnostic value; Immunoglobulin; Test results; Therapeutic effect