赭毒素A的神经毒性机制

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Quality Assurance and Safety of Crops & Foods Pub Date : 2021-04-27 DOI:10.15586/QAS.V13I2.837

F. Nourbakhsh, E. Tajbakhsh

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引用次数: 28

摘要

真菌毒素，如赭毒素，在自然界中广泛分布，是人类食品中常见的污染物。赭毒素是一组由多种霉菌产生的真菌毒素。Ochratoxin A（OTA）是该毒素家族中最突出的成员，由各种曲霉和青霉产生。OTA经常出现在谷物、含油种子、咖啡和肉制品等食品中。这种真菌毒素被描述为致畸、基因毒性、致癌和免疫毒性，并已被证明是一种强效神经毒素。本文对OTA的神经毒性进行了综述和讨论。神经毒性的主要可能机制是DNA氧化、蛋白质和脂质损伤以及细胞凋亡。然而，还需要进一步的研究来总结OTA的确切神经毒性机制，并找到减少OTA诱导的神经毒性的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Neurotoxicity mechanism of Ochratoxin A

Mycotoxins, such as Ochratoxins, are widely distributed in nature and are common contaminants of human foodstuffs. Ochratoxins are a group of mycotoxins produced by a wide range of molds. Ochratoxin A (OTA), the most prominent member of this toxin family, is produced by various Aspergillus and Penicillium species. OTA is frequently found in foods such as cereals, oleaginous seeds, coffee, and meat products. This mycotoxin has been described as teratogenic, genotoxic, carcinogenic, and immunotoxic, and has been proven to be a potent neurotoxin. In the present study, the neurotoxicological perspective of OTA was reviewed and discussed. The main possible mechanisms of neurotoxicity are oxidative DNA, protein and lipid damage, and apoptosis. However, further studies are needed to conclude the exact neurotoxicity mechanism of OTA and find the approaches that reduce the neurotoxicity induced by OTA.

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.