Favorable Outcomes Following the Use of Triple Therapy in a Patient with Osmotic Demyelination Syndrome

INTRODUCTION Osmotic Demyelination Syndrome (ODS) occurs following rapid overcorrection of hyponatremia.1 It is characterized by destruction of neuronal myelin sheaths in either the central area of the pons or in other susceptible areas causing severe irreversible neurologic deficits. Methods described in the literature suggested varying sodium correction rates which lead to different definitions of overcorrection of hyponatremia.2 The incidence of ODS consequently would be expected to increase. However, no general consensus exists regarding the optimal treatment regimen for this disease. Nevertheless, evidence-based management is essential for those who are diagnosed. We present a case of ODS treated with plasmapheresis (PP), intravenous immunoglobulins (IVIG), and intravenous methylprednisolone with significant recovery of neurologic function.