3-氨基-1,2,4-三嗪与偶联试剂和亲电试剂的反应

IF 1.3 3区化学 Q3 CHEMISTRY, ORGANIC

Heterocyclic Communications Pub Date : 2022-01-01 DOI:10.1515/hc-2022-0149

M. V. Bvumbi, Anza Imanuel Nemudzivhadi, Musiiwa Victoria Sengane, Simon Mnyakeni Moleele

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引用次数: 0

摘要

摘要在钯催化剂的作用下，3-氨基-1,2,4-三嗪与偶联剂如硼酸和末端炔反应得到了一个新的杂环体系的类似物。其它反应，如5位三嗪的胺化反应，随后与异氰酸苯酯和苯甲酰氯化物发生亲电反应，形成新的单脲和苯甲酰化合物。

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Reactions of 3-amino-1,2,4-triazine with coupling reagents and electrophiles

Abstract Analogs of a new heterocyclic system were obtained from the reactions of 3-amino-1,2,4-triazine with coupling reagents such as boronic acids, and terminal alkynes in the presence of a palladium catalyst. Other reactions such as amination of the triazine at position 5, followed by electrophilic reactions with phenyl isocyanates and benzoyl chlorides, were performed to form new monoureido and benzoylated compounds.

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来源期刊

Heterocyclic Communications 化学-有机化学

CiteScore

3.80

自引率

4.30%

发文量

审稿时长

1.4 months

期刊介绍： Heterocyclic Communications (HC) is a bimonthly, peer-reviewed journal publishing preliminary communications, research articles, and reviews on significant developments in all phases of heterocyclic chemistry, including general synthesis, natural products, computational analysis, considerable biological activity and inorganic ring systems. Clear presentation of experimental and computational data is strongly emphasized. Heterocyclic chemistry is a rapidly growing field. By some estimates original research papers in heterocyclic chemistry have increased to more than 60% of the current organic chemistry literature published. This explosive growth is even greater when considering heterocyclic research published in materials science, physical, biophysical, analytical, bioorganic, pharmaceutical, medicinal and natural products journals. There is a need, therefore, for a journal dedicated explicitly to heterocyclic chemistry and the properties of heterocyclic compounds.