注意力缺陷/多动障碍患儿执行功能障碍与血清神经胶质源性神经营养因子水平的相关性分析

中华行为医学与脑科学杂志 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.CN371468-20190606-00372

Na Liu, Y. Sang, Jiao Chen, Xiaoming Liu

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引用次数: 0

摘要

目的探讨注意力缺陷多动障碍（ADHD）患儿执行功能障碍与血清胶质源性神经营养因子（GDNF）水平的相关性。方法选择32例无药物ADHD患者和34例性别、年龄、智商匹配的正常儿童。使用数字跨度背向测试（DSB-T）、线索制作测试（TMT）、语义流利性测试（SFT）和Stroop颜色词测试（SCW-T）评估执行功能，并通过酶联免疫吸附试验（ELISA）测量外周GDNF水平。比较各组执行功能测试得分和血清GDNF水平，然后通过Spearman或pearson相关分析分析执行功能障碍与GDNF之间的相关性。结果（1）ADHD组的DSB-T和SFT评分均低于正常对照组（DSB-T4:（2）vs 5（1）；SFT（13.66±2.34）vs（15.21±2.13）（Z=3.16，t=2.82，均P<0.05），TMT-A和TMT-B耗时均高于正常对照组（TMT-A（61.12±19.03）s vs（48.76±21.06）s；TMT-B（158.66±63.78）s vs（123.62±45.24）s，t=2.50，2.59，二者均P<0.05）。ADHD组SCW-t的词色消耗、词干扰和词色误差均高于正常对照组（词色消耗（56.41±21.65）svs（45.97±13.42）s；单词干扰27（25）s vs 20（15）s；单词颜色错误4（3）vs 2（1），差异有统计学意义（t=2.37，Z=2.31，2.11，均P<0.05）。（2）ADHD组血清GDNF水平低于正常对照组（（481.59±68.74）pg/ml vs（552.47±110.13）pg/ml），差异具有统计学意义（t=3.11，P<0.05），血清GDNF水平与TMT-A、TMT-B和SCW-T单词干扰表现呈负相关（r=-0.512，r=-0.578，r=-0.432，均P<0.05），与DSB-T表现呈正相关（r=0.381，P<0.05）。关键词：注意力缺陷多动障碍；胶质源性神经营养因子；执行职能；儿童

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Correlation analysis between executive dysfunction and serum glial-derived neurotrophic factor level in children with attention deficit/hyperactivity disorder

Objective To explore the correlation between executive dysfunction and serum glial-derived neurotrophic factor (GDNF) levels in children with attention deficit hyperactivity disorder (ADHD). Methods 32 drug-free ADHD patients and 34 normal children matched in gender, age and IQ were included.The executive function was assessed using Digital Span Back Test (DSB-T), Trail Making Test (TMT), Semantic Fluency Test (SFT) and Stroop Color Word Test (SCW-T), and peripheral GDNF levels were measured by the enzyme linked immunosorbent assay (ELISA). The executive functional test scores and serum GDNF levels were compared between groups, and then the correlation between executive dysfunction and GDNF was analyzed by Spearman or pearson correlation analysis. Results (1) In the ADHD group, the DSB-T and SFT scores were lower than those in the normal control group(DSB-T4: (2) vs 5(1); SFT(13.66±2.34) vs (15.21±2.13)(Z=3.16, t=2.82, both P<0.05) and the TMT-A and TMT-B time-consuming were higher than those in the normal control group(TMT-A(61.12±19.03)s vs (48.76±21.06)s; TMT-B(158.66±63.78)s vs (123.62±45.24)s, t=2.50, 2.59, both P<0.05). The Word color consumption, word interference and word color errors of SCW-T in ADHD group were higher than those in the normal control group(Word color consumption(56.41±21.65)s vs (45.97±13.42)s; word interference 27(25)s vs 20(15)s; word color errors 4(3) vs 2(1)), and the differences were statistically significant(t=2.37, Z=2.31, 2.11, all P<0.05). (2) Serum levels of GDNF in the ADHD group were lower than that in the normal control group((481.59±68.74)pg/ml vs (552.47±110.13)pg/ml) , and the difference was statistically significant (t=3.11, P<0.05). (3) In the ADHD group, serum GDNF levels were negatively correlated with TMT-A, TMT-B and SCW-T word interference performance (r=-0.512, r=-0.578, r=-0.432, all P<0.05), and positively correlated with DSB-T performance(r=0.381, P<0.05). Conclusion Executive function is extensively damaged in ADHD patients, and GDNF may be involved in the pathophysiology of executive impairment. Key words: Attention deficit hyperactivity disorder; Glial-derived neurotrophic factor; Executive function; Children

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来源期刊

中华行为医学与脑科学杂志

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8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.