含和不含屈螺酮的联合口服避孕药血栓栓塞风险的比较：一项荟萃分析

IF 0.7 4区医学 Q4 OBSTETRICS & GYNECOLOGY

Reproductive and Developmental Medicine Pub Date : 2021-07-01 DOI:10.4103/2096-2924.324822

Wanlin Zhang, Zhe Dong, Jun Zhang, M. Lyu, Wei Zhang, Jian-Lei Huang, Xin Yang

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引用次数: 0

摘要

本研究旨在评估使用含有屈螺酮（DRSP）的联合口服避孕药（COCs）后发生静脉血栓栓塞（VTE）、动脉血栓栓塞（ATE）和其他副作用的风险。与不含DRSP的COCs相比，在整个研究人群中，含DRSP COCs将VTE的风险降低了15%，尽管这在统计学上并不显著（调整后的危险比/风险比[95%置信区间]0.85[0.69，1.04]）。含DRSP COCs在ATE风险方面也显示出显著的益处。服用含有COCs的DRSP 6个月后，受试者的体重指数显著下降0.64 kg/m2。我们得出的结论是，含有COCs的DRSP是安全的，可以广泛推荐使用。

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Comparison of risks of thromboembolism of drospirenone-containing and nondrospirenone -containing combined oral contraceptive use: A meta-analysis

This study aimed to estimate the risk of venous thromboembolism (VTE), arterial thromboembolism (ATE), and other side effects following the use of drospirenone (DRSP)-containing combined oral contraceptives (COCs). When compared with non-DRSP-containing COCs, DRSP-containing COCs decreased the risk of VTE by 15% in the overall study population, although this was not statistically significant (adjusted hazard ratio/risk ratio [95% confidence interval] 0.85 [0.69, 1.04]). DRSP-containing COCs also showed significant benefits in terms of ATE risk. The body mass index of the subjects significantly decreased by 0.64 kg/m2 after taking the DRSP-containing COCs for 6 months. We concluded that DRSP-containing COCs were safe for use and could be broadly recommended.

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