加拿大阿尔伯塔省疫苗接种后(2021年3月- 2021年7月)SARS-CoV-2血清阳性

IF 4 4区 医学 Q1 INFECTIOUS DISEASES
J. Kanji, L. Nguyen, S. Plitt, C. Charlton, J. Fenton, S. Braun, Carol Marohn, Cheryl Lau, L. Svenson, Deena Hinshaw, Christie Lutsiak, N. Zelyas, Michael Mengel, G. Tipples
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Results 60,632 individual blood samples were tested. Vaccination data were available for 98.8% of samples. Adjusted RBD IgG positivity rose from 11.9% (95% confidence interval [CI] 11.9–12.0%) in March 2021 to 70.2% (95% CI 70.2–70.3%) in July 2021 (p < .0001). Seropositivity rose from 9.4% (95% CI 9.3–9.4%) in March 2021 to 20.2% (95% CI 20.1–20.2%) in July 2021 in unvaccinated Albertans. Unvaccinated seropositive individuals were from geographic areas with significantly (p < .001) lower median household income, lower proportion of married/common-law relationships, larger average household size and higher proportions of visible minorities compared to seronegative unvaccinated individuals. In July 2021, the age groups with the lowest and highest seropositivity in unvaccinated Albertans were those ≥80 years (12.0%, 95% CI 5.3–18.6%) and 20–29 years (24.2%, 95% CI 19.6–28.8%), respectively. 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引用次数: 1

摘要

背景2019冠状病毒病大流行迫切需要快速做出公共卫生决策。我们系统评估SARS-CoV-2血清阳性,以了解当地COVID-19流行病学,为循证公共卫生决策提供支持。方法于2021年2月26日至2021年7月9日在加拿大艾伯塔省6个临床实验室采集残血,每月1-5天检测SARS-CoV-2受体结合域(RBD) IgG。计算每月的原始和调整(年龄和性别)血清阳性。结果与省级行政、实验室和疫苗数据库相关联。结果共检测了60632份血样。98.8%的样本可获得疫苗接种资料。调整后的RBD IgG阳性从2021年3月的11.9%(95%可信区间[CI] 11.9-12.0%)上升到2021年7月的70.2% (95% CI 70.2-70.3%) (p < 0.0001)。未接种疫苗的艾伯塔省人的血清阳性从2021年3月的9.4% (95% CI 9.3-9.4%)上升到2021年7月的20.2% (95% CI 20.1-20.2%)。与未接种疫苗的血清阴性个体相比,未接种疫苗的血清阳性个体来自家庭收入中位数显著(p < 0.001)较低、已婚/普通法关系比例较低、平均家庭规模较大和少数族裔比例较高的地理区域。2021年7月,未接种疫苗的艾伯塔省人血清阳性率最低和最高的年龄组分别为≥80岁(12.0%,95% CI 5.3-18.6%)和20-29岁(24.2%,95% CI 19.6-28.8%)。在未接种疫苗的血清阳性个体中,50.2% (95% CI 45.9-54.5%)没有先前的SARS-CoV-2分子检测记录。结论对SARS-CoV-2血清学阳性进行纵向监测,具有数据联系性,对大流行期间的决策有一定的参考价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seropositivity to SARS-CoV-2 in Alberta, Canada in a post-vaccination period (March 2021–July 2021)
Abstract Background The COVID-19 pandemic has necessitated the need to rapidly make public health decisions. We systematically evaluated SARS-CoV-2 seropositivity to understand local COVID-19 epidemiology and support evidence-based public health decision making. Methods Residual blood samples were collected for SARS-CoV-2 receptor binding domain (RBD) IgG testing over a 1–5 day period monthly from 26 February 2021–9 July 2021 from six clinical laboratories across the province of Alberta, Canada. Monthly crude and adjusted (for age and gender) seropositivity were calculated. Results were linked to provincial administrative, laboratory, and vaccine databases. Results 60,632 individual blood samples were tested. Vaccination data were available for 98.8% of samples. Adjusted RBD IgG positivity rose from 11.9% (95% confidence interval [CI] 11.9–12.0%) in March 2021 to 70.2% (95% CI 70.2–70.3%) in July 2021 (p < .0001). Seropositivity rose from 9.4% (95% CI 9.3–9.4%) in March 2021 to 20.2% (95% CI 20.1–20.2%) in July 2021 in unvaccinated Albertans. Unvaccinated seropositive individuals were from geographic areas with significantly (p < .001) lower median household income, lower proportion of married/common-law relationships, larger average household size and higher proportions of visible minorities compared to seronegative unvaccinated individuals. In July 2021, the age groups with the lowest and highest seropositivity in unvaccinated Albertans were those ≥80 years (12.0%, 95% CI 5.3–18.6%) and 20–29 years (24.2%, 95% CI 19.6–28.8%), respectively. Of seropositive unvaccinated individuals, 50.2% (95% CI 45.9–54.5%) had no record of prior SARS-CoV-2 molecular testing. Conclusions Longitudinal surveillance of SARS-CoV-2 seropositivity with data linkage is valuable for decision-making during the pandemic.
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来源期刊
Infectious Diseases
Infectious Diseases INFECTIOUS DISEASES-
CiteScore
8.20
自引率
1.70%
发文量
92
审稿时长
8 weeks
期刊介绍: Infectious Diseases (formerly Scandinavian Journal of Infectious Diseases) is a peer-reviewed journal publishing articles on all aspects of human infection, including pathogenesis, diagnosis, and treatment of infectious diseases, and also on medical microbiology and epidemiology
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