Infectious Diseases最新文献

The silent invaders: Oropouche and Melao viruses, causes of increased public health risks for the Americas. 无声的入侵者：奥罗普切病毒和梅劳病毒，美洲公共卫生风险增加的原因。

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-09-17 DOI: 10.1080/23744235.2024.2403712

Kirk Osmond Douglas

{"title":"The silent invaders: Oropouche and Melao viruses, causes of increased public health risks for the Americas.","authors":"Kirk Osmond Douglas","doi":"10.1080/23744235.2024.2403712","DOIUrl":"https://doi.org/10.1080/23744235.2024.2403712","url":null,"abstract":"The Oropouche virus (OROV) is emerging as a major public health threat worldwide, yet for the Americas, it raises complex challenges that intersect with other existing arboviral threats such as Zika (ZIKV), dengue (DENV) and Chikungunya (CHIKV) viruses. Originating from Trinidad and Tobago in 1955, it has spread across the Amazonian Basin and more recently into the Caribbean (Cuba and Haiti) and Europe, highlighting the importance of air travel in its dissemination. OROV and the less studied Melao virus (MELV), pose significant laboratory diagnostic challenges particularly in regions co-endemic with other arboviral diseases, such as dengue and Zika fever. The effects of climate change, particularly in the Caribbean, may exacerbate the transmission of these viruses by exposing human exposure risk to vectors. Public health systems in the Americas are under strain due to complex clinical management of these infections necessitating enhanced surveillance, clinical vigilance, diagnostics and vector control. Vulnerable populations, including pregnant women, elderly, and young children, are at a heightened risk, which raises concerns about the impact on medical tourism in the region. To mitigate the spread and impact of OROV and MELV, recommendations include increased clinical surveillance, improved laboratory diagnostics, public health communication, and strengthened vector controls. Robust research and capacity building (including training and education) efforts are essential to address knowledge gaps and effectively manage future OROV and MELV outbreaks in the Americas.","PeriodicalId":13671,"journal":{"name":"Infectious Diseases","volume":"9 1","pages":"1-6"},"PeriodicalIF":5.8,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the 2023 Duke-ISCVID criteria for infective endocarditis in patients referred to the Lund infective endocarditis team. 对转诊至伦德感染性心内膜炎团队的患者中感染性心内膜炎的 2023 杜克-ISCVID 标准进行评估。

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-09-13 DOI: 10.1080/23744235.2024.2402374

Nils Avogadri,Alex Ivarsson,Charlotte Burup Kristensen,Sigurdur Ragnarsson,Magnus Rasmussen

{"title":"Evaluation of the 2023 Duke-ISCVID criteria for infective endocarditis in patients referred to the Lund infective endocarditis team.","authors":"Nils Avogadri,Alex Ivarsson,Charlotte Burup Kristensen,Sigurdur Ragnarsson,Magnus Rasmussen","doi":"10.1080/23744235.2024.2402374","DOIUrl":"https://doi.org/10.1080/23744235.2024.2402374","url":null,"abstract":"BACKGROUNDThe Duke criteria for diagnosing infective endocarditis (IE) were recently updated by the International Society for Cardiovascular Infectious Diseases (ISCVID) with the purpose of enhancing diagnostic specificity and sensitivity. This study investigated the performance of the Duke-ISCVID criteria in relation to previous criteria.METHODThis retrospective single centre cohort study included patients referred to the Lund IE Team (LIET) between 2017 and 2022, and compared episodes classified according to the 2000 modified Duke, European Society of Cardiology (ESC) 2015, and 2023 Duke-ISCVID criteria. The LIET's decision to treat episodes as IE served as the reference standard.RESULTSThe study cohort comprised 661 episodes of potential IE. The LIET classified 498 (75%) episodes as IE. The Duke-ISCVID criteria classified a slightly higher proportion of episodes as definite IE (56.4%) compared to the ESC 2015 criteria (54.9%), and the modified Duke (51.1%). The Duke-ISCVID criteria had higher sensitivity (72.5%) for definite IE compared to ESC 2015 (70.7%, p = .57) and modified Duke (66.1%, p = .033). The specificities were similar for the Duke-ISCVID criteria (92.6%), compared to ESC 2015 (93.9%, p = .83) and the modified Duke criteria (95.0%, p = .49). When considering both definite and possible IE positive, specificity for all criteria was low: 32.5% for the Duke-ISCVID criteria, 41.7% for ESC 2015 (p = .086), and 42.3% for modified Duke criteria (p = .11), while the sensitivity was not significantly lower.DISCUSSIONThe Duke-ISCVID criteria demonstrated slightly improved sensitivity for diagnosing IE whereas specificity remained unchanged. Further refinement of the Duke-ISCVID criteria is needed to balance sensitivity and specificity.","PeriodicalId":13671,"journal":{"name":"Infectious Diseases","volume":"12 1","pages":"1-9"},"PeriodicalIF":5.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142264228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical evaluation of a highly multiplexed CRISPR-based diagnostic assay for diagnosing lower respiratory tract infection: a prospective cohort study. 诊断下呼吸道感染的高度复用 CRISPR 诊断测定的临床评估：一项前瞻性队列研究。

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-09-12 DOI: 10.1080/23744235.2024.2402921

Hui Lou,Xiaojia Wang,Qiuting Jiang,Xi Li,Yake Yao,Qi Chen,Linxing Chen,Shanshan Zhang,Yunsong Yu,Chao Liu,Hua Zhou

{"title":"Clinical evaluation of a highly multiplexed CRISPR-based diagnostic assay for diagnosing lower respiratory tract infection: a prospective cohort study.","authors":"Hui Lou,Xiaojia Wang,Qiuting Jiang,Xi Li,Yake Yao,Qi Chen,Linxing Chen,Shanshan Zhang,Yunsong Yu,Chao Liu,Hua Zhou","doi":"10.1080/23744235.2024.2402921","DOIUrl":"https://doi.org/10.1080/23744235.2024.2402921","url":null,"abstract":"OBJECTIVEAccurate and rapid identification of causative pathogens is essential to guide the clinical management of lower respiratory tract infections (LRTIs). Here we conducted a single-centre prospective study in 284 patients suspected of lower respiratory tract infections to evaluate the utility of a nucleic acid test based on highly multiplexed polymerase chain reaction (PCR) and CRISPR-Cas12a.METHODSWe determined the analytical and diagnostic performance of the CRISPR assay using a combination of reference standards, including conventional microbiological tests (CMTs), metagenomic Next-Generation Sequencing (mNGS), and clinical adjudication by a panel of experts on infectious diseases and microbiology.RESULTSThe CRISPR assay showed a higher detection rate (63.0%) than conventional microbiological tests (38.4%) and was lower than metagenomic Next-Generation Sequencing (72.9%). In detecting polymicrobial infections, the positivity rate of the CRISPR assay (19.4%) was higher than conventional microbiological tests (3.5%) and lower than metagenomic Next-Generation Sequencing (28.9%). The overall diagnostic sensitivity of the CRISPR assay (67.8%) was higher than conventional microbiological tests (41.8%), and lower than metagenomic Next-Generation Sequencing (93.2%).CONCLUSIONSConsidering the low cost, ease of operation, short turnaround time, and broad range of pathogens detected in a single test, the CRISPR assay has the potential to be implemented as a screening tool for the aetiological diagnosis of lower respiratory tract infections patients, especially in cases where atypical bacteria or coinfections are suspected.","PeriodicalId":13671,"journal":{"name":"Infectious Diseases","volume":"18 1","pages":"1-11"},"PeriodicalIF":5.8,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142204893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First cases of mpox Clade I outside of Africa: genetic insights on its evolution. 非洲以外的首例 mpox Clade I：对其进化的遗传学见解。

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-09-11 DOI: 10.1080/23744235.2024.2399776

Francesco Branda,Giancarlo Ceccarelli,Massimo Ciccozzi,Fabio Scarpa

引用次数: 0

Trends in decision-making by primary care physicians regarding common infectious complaints 初级保健医生对常见感染性主诉的决策趋势

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-22 DOI: 10.1080/23744235.2024.2344795

Anat Reiner-Benaim, Shimon Amar

引用次数: 0

Dengue hospitalizations and in-hospital mortality changes in trend in Ecuador: a nationwide study from 2015 to 2022 厄瓜多尔登革热住院人数和院内死亡率变化趋势：2015 年至 2022 年全国范围内的研究

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-15 DOI: 10.1080/23744235.2024.2341871

German Josuet Lapo-Talledo

引用次数: 0

Measles in Czech population with varying vaccination rates in 2018–2019: clinical and laboratory differences between vaccinated and unvaccinated individuals and their relevance to clinical practice 2018-2019年捷克不同疫苗接种率人群中的麻疹：接种疫苗和未接种疫苗人群的临床和实验室差异及其与临床实践的相关性

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-13 DOI: 10.1080/23744235.2024.2339870

Dita Smíšková, Simona Janovic, Pavlína Kadeřávková, Ludmila Nováková, Zuzana Blechová, Marek Malý, Radomíra Limberková

引用次数: 0

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-12 DOI: 10.1080/23744235.2024.2340728

Ugo Fedeli, Claudio Barbiellini Amidei, Evelina Tacconelli, Elena Carrara

引用次数: 0

Syndromic testing for respiratory pathogens but not National Early Warning Score can be used to identify viral cause in hospitalised adults with lower respiratory tract infections 在下呼吸道感染住院成人患者中，呼吸道病原体的综合检测可用于确定病毒病因，但国家预警评分不可用于确定病毒病因

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-02 DOI: 10.1080/23744235.2024.2333973

Susanna Bergbrant, Nicklas Sundell, Lars-Magnus Andersson, Magnus Lindh, Lars Gustavsson, Johan Westin

引用次数: 0

Elevated levels of serum muscle enzymes in the initial phase of tick-borne encephalitis 蜱传脑炎初期血清肌酶水平升高

IF 5.8 4区医学

Infectious Diseases Pub Date : 2024-04-02 DOI: 10.1080/23744235.2024.2335349

Petra Bogovič, Stanka Lotrič-Furlan, Katarina Ogrinc, Tatjana Avšič Županc, Miša Korva, Andrej Kastrin, Alenka Trampuš Bakija, Klemen Strle, Franc Strle

引用次数: 0