开发用于生物医学应用的分级微针

Q1 Medicine
Minhui Lu , Xiaoxuan Zhang , Zhiqiang Luo , Yuanjin Zhao
{"title":"开发用于生物医学应用的分级微针","authors":"Minhui Lu ,&nbsp;Xiaoxuan Zhang ,&nbsp;Zhiqiang Luo ,&nbsp;Yuanjin Zhao","doi":"10.1016/j.engreg.2023.04.004","DOIUrl":null,"url":null,"abstract":"<div><p>As a new kind of microcarrier device, microneedles are featured by micrometer needle arrays with an overall size in the centimeter scale. Due to the needle shape and the micron size, microneedles can penetrate the skin without harming nerves and blood vessels, which causes many advantages such as minimally invasive, safe and convenient. The past few decades have witnessed a great leap in microneedles research. The main materials of microneedles have changed from metal and ceramic to polymers with more complex functions, and the optimization of materials and preparation strategies has led to a greater variety of microneedle styles. Among them, the construction or combination of smaller size structures or materials on microneedles to fabricate hierarchical microneedles is a major research hotspot. Here, we present the recent research progress of hierarchical microneedles for biomedicine. We begin by discussing the fabrication strategies of hierarchical microneedles, including mainstream casting and coating methods based on microneedle molds and three dimensions (3D) printing methods. We then expand the discussion from the hierarchical microneedles with porous structure to those composited with nanomaterials. Eventually, we have a discussion about the research progress of hierarchical microneedles in the area of biomarkers detection and transdermal drug delivery, as well as its future development direction.</p></div>","PeriodicalId":72919,"journal":{"name":"Engineered regeneration","volume":"4 3","pages":"Pages 316-327"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Developing hierarchical microneedles for biomedical applications\",\"authors\":\"Minhui Lu ,&nbsp;Xiaoxuan Zhang ,&nbsp;Zhiqiang Luo ,&nbsp;Yuanjin Zhao\",\"doi\":\"10.1016/j.engreg.2023.04.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>As a new kind of microcarrier device, microneedles are featured by micrometer needle arrays with an overall size in the centimeter scale. Due to the needle shape and the micron size, microneedles can penetrate the skin without harming nerves and blood vessels, which causes many advantages such as minimally invasive, safe and convenient. The past few decades have witnessed a great leap in microneedles research. The main materials of microneedles have changed from metal and ceramic to polymers with more complex functions, and the optimization of materials and preparation strategies has led to a greater variety of microneedle styles. Among them, the construction or combination of smaller size structures or materials on microneedles to fabricate hierarchical microneedles is a major research hotspot. Here, we present the recent research progress of hierarchical microneedles for biomedicine. We begin by discussing the fabrication strategies of hierarchical microneedles, including mainstream casting and coating methods based on microneedle molds and three dimensions (3D) printing methods. We then expand the discussion from the hierarchical microneedles with porous structure to those composited with nanomaterials. Eventually, we have a discussion about the research progress of hierarchical microneedles in the area of biomarkers detection and transdermal drug delivery, as well as its future development direction.</p></div>\",\"PeriodicalId\":72919,\"journal\":{\"name\":\"Engineered regeneration\",\"volume\":\"4 3\",\"pages\":\"Pages 316-327\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Engineered regeneration\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666138123000348\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Engineered regeneration","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666138123000348","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

微针是一种新型的微载体器件,其特点是微米级的针阵列,整体尺寸在厘米级。由于针头的形状和微米大小,微针可以穿透皮肤而不伤害神经和血管,从而具有微创,安全,方便等诸多优点。过去几十年见证了微针研究的巨大飞跃。微针的主要材料已经从金属和陶瓷转变为功能更复杂的聚合物,材料和制备策略的优化使得微针的样式更加多样。其中,在微针上构建或组合更小尺寸的结构或材料来制造分层微针是一个主要的研究热点。本文就分层微针在生物医学领域的研究进展作一综述。我们首先讨论了分层微针的制造策略,包括基于微针模具的主流铸造和涂层方法以及三维(3D)打印方法。然后,我们将讨论从具有多孔结构的分层微针扩展到与纳米材料复合的微针。最后,我们讨论了分层微针在生物标志物检测和透皮给药领域的研究进展,以及未来的发展方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Developing hierarchical microneedles for biomedical applications

As a new kind of microcarrier device, microneedles are featured by micrometer needle arrays with an overall size in the centimeter scale. Due to the needle shape and the micron size, microneedles can penetrate the skin without harming nerves and blood vessels, which causes many advantages such as minimally invasive, safe and convenient. The past few decades have witnessed a great leap in microneedles research. The main materials of microneedles have changed from metal and ceramic to polymers with more complex functions, and the optimization of materials and preparation strategies has led to a greater variety of microneedle styles. Among them, the construction or combination of smaller size structures or materials on microneedles to fabricate hierarchical microneedles is a major research hotspot. Here, we present the recent research progress of hierarchical microneedles for biomedicine. We begin by discussing the fabrication strategies of hierarchical microneedles, including mainstream casting and coating methods based on microneedle molds and three dimensions (3D) printing methods. We then expand the discussion from the hierarchical microneedles with porous structure to those composited with nanomaterials. Eventually, we have a discussion about the research progress of hierarchical microneedles in the area of biomarkers detection and transdermal drug delivery, as well as its future development direction.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Engineered regeneration
Engineered regeneration Biomaterials, Medicine and Dentistry (General), Biotechnology, Biomedical Engineering
CiteScore
22.90
自引率
0.00%
发文量
0
审稿时长
33 days
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信