百里醌对环磷酰胺致大鼠卵巢氧化及炎性损伤的影响

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2022-09-06 DOI:10.3329/bjp.v17i3.59418

Cagdas Colluoglu, S. Balci, B. Gundogdu, T. Coban, S. Bulut, H. Suleyman

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引用次数: 0

摘要

本研究旨在研究胸腺醌对环磷酰胺可能引起的雌性大鼠卵巢损伤和不孕的影响。实验中的大鼠（n=36）被分为三组；环磷酰胺给药、胸腺醌加环磷酰胺给药和健康对照。给药30天后，每组6只大鼠处死，并对卵巢组织进行生化和组织病理学检查。其余动物与成年雄性大鼠一起被关在同一笼子里两个月。83%的环磷酰胺组动物出现不孕。胸腺醌减轻了环磷酰胺相关的氧化和炎症性卵巢损伤，并减少了不孕的发生。研究结果表明，胸腺肽醌可能有助于治疗因氧化和炎症性卵巢损伤引起的不孕不育。

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Effect of thymoquinone on cyclophosphamide-induced oxidative and inflammatory ovarian damage in rat

This study intends to investigate the effect of thymoquinone against possible ovarian damage and infertility caused by cyclophosphamide in female rats. The rats in the experiment (n=36) were separated into three groups; cyclophosphamide administered, thymoquinone plus cyclophosphamide administered and healthy control. At the end of 30 days of administration, 6 rats from each group were killed and the biochemical and histopathological examina-tions were performed on the ovarian tissues. The remaining animals were kept in the same cage with mature male rats for two months. Infertility developed in 83% of cyclophosphamide group animals. Thymoquinone attenuated cyclophosphamide-related oxidative and inflammatory ovarian damage and reduced the development of infertility. The outcomes suggest that thymoquinone may be useful in treating infertility due to oxidative and inflammatory ovarian damage.

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.