睾酮凝胶对IVF周期前卵巢反应差的患者的影响:它真的有效吗?

Q4 Pharmacology, Toxicology and Pharmaceutics

International Journal of Drug Delivery Technology Pub Date : 2023-03-25 DOI:10.25258/ijddt.13.1.46

E. M. Muhammed, Zainab H Al khafajy, H. Rasool

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引用次数: 0

摘要

背景：传统上，贫穷妇女的反应是产妇年龄大，卵巢几乎没有备用状态。尽管如此，一些女性对测量的卵巢刺激几乎没有反应。本研究的目的：评估经皮睾酮凝胶（TTG）在控制性卵巢刺激（COS）前对接受卵浆内精子注射（ICSI）的不良反应者的有效性。方法：一项干预性前瞻性随机对照试验，包括60名女性，她们被定义为接受卵浆内单精子注射（ICSI）程序的不幸应答者。人群被分成两组。大约30名患者接受了10 mg TTG，在ICSI透皮睾酮凝胶（TTG）COS预处理组之前的周期中每天施用21天，而其他30名患者为对照组。再次评估所有患者的AFC，并在月经周期开始时开始体外受精（IVF）治疗。研究组再次测量血清睾酮。主要结果是回收卵母细胞的数量，而次要结果是移植胚胎的数量和质量，化学妊娠率。结果：两组之间的社会人口学特征没有显著差异。研究组的卵母细胞总数也有所增加，但这种差异仍然不显著。尽管研究组的促性腺激素（GT）总剂量和刺激天数较少，但这在静态上并不显著。在胚胎数量和分级、化学妊娠率和临床妊娠率方面没有经验差异。结论：在接受ICSI的不良反应者中，10 mg/天的透皮睾酮预处理21天并没有使卵母细胞回收数量、胚胎数量或妊娠率上升到显著水平

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The Eff ect of Testosterone Gel for Patients with Poor Ovarian Response Prior to IVF Cycles: Is It really Eff ective?

Background: Classically, poor women respond with old maternal age and little ovarian standby. Though, some females unpredictably have little reply to measured ovarian stimulation. Aim of the Study: To evaluate the eff ectiveness of transdermal testosterone gel (TTG) before controlled ovarian stimulation (COS) in poor responders undergoing intracytoplasmic sperm injection (ICSI). Methods: An interventional prospective randomized control trial that included 60 females who were defi nite as unfortunate responders undergoing an intracytoplasmic sperm injection (ICSI) procedure. The population was divided into two groups. Approximately 30 patients received 10 mg TTG that was applied daily for 21 days in the cycle preceding COS for ICSI Transdermal testosterone gel (TTG) pretreatment group, while the other 30 patients are the control group. All patients were assessed for their AFC again and to begin in-vitro futilization (IVF) treatment with the beginning of the menstrual cycle. Serum testosterone was measured again in the study group. The primary outcome is the number of retrieved oocytes while the secondary outcome is the number and quality of embryos transferred, chemical gestation rate. Results: No important diff erences in sociodemographic features between both groups compared. Also there was an increase in total number of oocytes in the study group but again, this diff erence was statically non-signifi cant. Although the total dose of gonadotrophin (GT) and the duration of stimulation days were less in study group but this was statically non-signifi cant. No diff erences experiential regarding number and grading of embryos, chemical pregnancy rate nor clinical pregnancy rate. Conclusion: Pretreatment of transdermal testosterone at a dose of 10 mg/day for 21 days not upsurge the number of oocyte retrieved nor the number of embryos or pregnancy rate to a signifi cant level in poor responders undergoing ICSI

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来源期刊

International Journal of Drug Delivery Technology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： International Journal of Drug Delivery Technology (IJDDT) provides the forum for reporting innovations, production methods, technologies, initiatives and the application of scientific knowledge to the aspects of pharmaceutics, including controlled drug release systems, drug targeting etc. in the form of expert forums, reviews, full research papers, and short communications.