抗体介导的脑炎的当代进展:抗lgi1和抗caspr2抗体(Ab)介导的脑肽

IF 8.3 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2022-05-01 DOI:10.1016/j.autrev.2022.103074

Nabil Seery , Helmut Butzkueven , Terence J. O’Brien , Mastura Monif

{"title":"抗体介导的脑炎的当代进展:抗lgi1和抗caspr2抗体(Ab)介导的脑肽","authors":"Nabil Seery , Helmut Butzkueven , Terence J. O’Brien , Mastura Monif","doi":"10.1016/j.autrev.2022.103074","DOIUrl":null,"url":null,"abstract":"<div><p><span>Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis<span>. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition<span> identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, </span></span></span>prognostic factors and clinical outcomes regarding these disorders.</p></div>","PeriodicalId":8664,"journal":{"name":"Autoimmunity reviews","volume":"21 5","pages":"Article 103074"},"PeriodicalIF":8.3000,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"8","resultStr":"{\"title\":\"Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides\",\"authors\":\"Nabil Seery , Helmut Butzkueven , Terence J. O’Brien , Mastura Monif\",\"doi\":\"10.1016/j.autrev.2022.103074\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p><span>Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis<span>. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition<span> identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, </span></span></span>prognostic factors and clinical outcomes regarding these disorders.</p></div>\",\"PeriodicalId\":8664,\"journal\":{\"name\":\"Autoimmunity reviews\",\"volume\":\"21 5\",\"pages\":\"Article 103074\"},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2022-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Autoimmunity reviews\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1568997222000441\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Autoimmunity reviews","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1568997222000441","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 8

摘要

具有针对富含亮氨酸的胶质瘤失活1 (LGI1)和接触蛋白样2 (Caspr2)抗体的脑肽代表了两种越来越明确的自身免疫性脑炎形式。两者具有重叠和独特的临床特征，由针对不同蛋白质的自身抗体介导，并与电压门控钾通道结合，具有迄今为止确定的独特遗传易感性。在这里，我们总结疾病机制，临床特点，治疗考虑，预后因素和临床结果有关这些疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides

查看原文本刊更多论文

Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides

Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, prognostic factors and clinical outcomes regarding these disorders.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.