原核胞杆菌亚目真核线粒体精氨酸- tRNA合成酶进化的分子证据

IF 3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

FEBS Letters Pub Date : 2019-11-09 DOI:10.1002/1873-3468.13665

G. Igloi

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引用次数: 4

摘要

真核生物氨基酰- tRNA合成酶家族的进化起源是所有生物体所必需的，这是一个有争议的问题。为了揭示精氨酸酰- tRNA合成酶的古老分子来源，我们从数据库中挖掘了1347个真核生物精氨酸酰- tRNA合成酶序列并进行了分析。它们的多序列比对揭示了一个特征序列，该序列是核编码酶的特征，该酶被导入线粒体。利用这个分子信标，这个基因的起源可以追溯到现代的原核生物。通过这种方式，先前的系统发育分析将黏液球菌与真核线粒体精氨酸酰tRNA合成酶的出现联系起来，这一分析得到了包括黏液球菌在内的胞杆菌亚目中独特的分子特征的支持。

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Molecular evidence for the evolution of the eukaryotic mitochondrial arginyl‐tRNA synthetase from the prokaryotic suborder Cystobacterineae

The evolutionary origin of the family of eukaryotic aminoacyl‐tRNA synthetases that are essential to all living organisms is a matter of debate. In order to shed molecular light on the ancient source of arginyl‐tRNA synthetase, a total of 1347 eukaryotic arginyl‐tRNA synthetase sequences were mined from databases and analyzed. Their multiple sequence alignment reveals a signature sequence that is characteristic of the nuclear‐encoded enzyme, which is imported into mitochondria. Using this molecular beacon, the origins of this gene can be traced to modern prokaryotes. In this way, a previous phylogenetic analysis linking Myxococcus to the emergence of the eukaryotic mitochondrial arginyl‐tRNA synthetase is supported by the unique existence of the molecular signature within the suborder Cystobacterineae that includes Myxococcus.

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来源期刊

FEBS Letters 生物-生化与分子生物学

CiteScore

6.60

自引率

2.90%

发文量

303

审稿时长

1 months

期刊介绍： FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.