甘油三酯与急性胰腺炎类型、严重程度及临床预后的相关性。

IF 0.7 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Clinical laboratory Pub Date : 2022-05-01 DOI:10.7754/Clin.Lab.2021.210727

Da Jiang, Junyu Wang, Shubin Guo

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引用次数: 1

摘要

背景本研究旨在探讨甘油三酯（TG）与急性胰腺炎（AP）的类型、严重程度和预后的相关性。方法选择2017年1月至2019年6月接受治疗的184例AP患者。分别通过改良计算机断层扫描严重程度指数（MCTSI）评分和序贯器官衰竭评估（SOFA）评分来评估严重程度和预后。将其分为胆汁性AP（BAP）组和高脂血症AP（HLAP）组，并比较其血脂水平。根据TG水平，将其分为正常组和升高组（>1.70 mmol/L），并比较一般数据、严重程度和预后。将升高组进一步分为轻度、中度和重度升高组，并比较其严重程度和预后。以是否存在严重AP（SAP）和全身炎症反应综合征（SIRS）为因变量进行Logistic回归分析。结果HLAP组TG、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白蛋白胆固醇（LDL-C）、载脂蛋白A1（Apo-A1）和载脂蛋白B水平均显著高于BAP组（p<0.05），与正常组相比，升高组SAP、SIRS和胸腔积液的病例数、MCTSI评分和SOFA评分显著升高，腹痛缓解时间和住院时间显著延长（p<0.05），严重升高组胸腔积液明显多于其他三组（p＜0.05），轻度和中度升高组SIRS病例数明显多于正常组（p＞0.05）。TG是SAP和SIRS的独立危险因素（p＜0.01）。结论TG升高的患者多为HLAP。TG水平越高，SAP发生率越高，SIRS发生率越低，AP患者预后越差。

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Correlations of Triglyceride with Type, Severity and Clinical Prognosis of Acute Pancreatitis.

BACKGROUND The aim of this study was to explore the correlations of triglyceride (TG) with type, severity, and prognosis of acute pancreatitis (AP). METHODS A total of 184 AP patients treated from January 2017 to June 2019 were selected. The severity and prognosis were assessed through modified computed tomography severity index (MCTSI) score and sequential organ failure assessment (SOFA) score, respectively. They were divided into biliary AP (BAP) and hyperlipidemic AP (HLAP) groups, and their blood lipid levels were compared. According to TG level, they were divided into normal and elevation groups (> 1.70 mmol/L), and the general data, severity, and prognosis were compared. The elevation group was further divided into mild, moderate, and severe elevation groups, and severity and prognosis were compared. Logistic regression analysis was performed with presence or absence of severe AP (SAP) and systemic inflammatory response syndrome (SIRS) as dependent variables. RESULTS The levels of TG, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (Apo-A1), and Apo-B in the HLAP group were significantly higher than those in the BAP group (p < 0.05). Age, gender ratio, and body mass index had significant differences between normal and elevation groups (p < 0.05). Compared with the normal group, the numbers of cases of SAP, SIRS and pleural effusion, MCTSI score and SOFA score significantly rose, and the relief time of abdominal pain and length of hospital stay were significantly prolonged in the elevation group (p < 0.05). The number of cases of SAP, SIRS, and pleural effusion was significantly greater in the severe elevation group than that in the other three groups (p < 0.05), and the number of SIRS cases was significantly greater in the mild and moderate elevation groups than that in the normal group (p < 0.05). TG was an independent risk factor for SAP and SIRS (p < 0.05). CONCLUSIONS Patients with TG elevation mostly suffer from HLAP. Higher TG level meant higher tendency of SAP, higher incidence rate of SIRS and worse prognosis of AP patients.

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来源期刊

Clinical laboratory 医学-医学实验技术

CiteScore

1.50

自引率

0.00%

发文量

494

审稿时长

3 months

期刊介绍： Clinical Laboratory is an international fully peer-reviewed journal covering all aspects of laboratory medicine and transfusion medicine. In addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies. The journal publishes original articles, review articles, posters, short reports, case studies and letters to the editor dealing with 1) the scientific background, implementation and diagnostic significance of laboratory methods employed in hospitals, blood banks and physicians'' offices and with 2) scientific, administrative and clinical aspects of transfusion medicine and 3) in addition to transfusion medicine topics Clinical Laboratory represents submissions concerning tissue transplantation and hematopoietic, cellular and gene therapies.