慢性疾病中的瓜氨酸-中性粒细胞胞外陷阱轴

IF 4.7 3区 医学 Q2 IMMUNOLOGY
M. Marônek, R. Gardlík
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引用次数: 2

摘要

蛋白质的瓜氨酸化对于中性粒细胞细胞外陷阱(NETs)的形成至关重要,NETs是在细胞外环境中与抗菌蛋白一起排出的核DNA链,以阻止病原体的传播。矛盾的是,NETs可能具有免疫原性,并导致炎症。众所周知,DNA的外化需要一组称为肽基精氨酸脱氨酶(PADs)的酶。目前的研究通常将慢性疾病中的瓜氨酸化、NET形成、PAD过表达和细胞外DNA(ecDNA)积累视为单独的事件。相反,我们提出,瓜氨酸化可以被视为自身免疫的主要机制,例如通过形成抗瓜氨酸蛋白抗体(ACPA),但也可以作为一个导致慢性炎症的过程。因此,瓜氨酸化可能是中心,连接并影响多种炎症性疾病,其中ACPA、NETs或ecDNA已经被记录在案。在这篇综述中,我们旨在强调瓜氨酸化在许多慢性疾病发病机制中的重要性,并探索瓜氨酸化NET轴的诊断、预后和治疗潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Citrullination-Neutrophil Extracellular Trap Axis in Chronic Diseases
Citrullination of proteins is crucial for the formation of neutrophil extracellular traps (NETs) – strands of nuclear DNA expulsed in the extracellular environment along with antimicrobial proteins in order to halt the spread of pathogens. Paradoxically, NETs may be immunogenic and contribute to inflammation. It is known that for the externalization of DNA, a group of enzymes called peptidyl arginine deiminases (PADs) is required. Current research often looks at citrullination, NET formation, PAD overexpression, and extracellular DNA (ecDNA) accumulation in chronic diseases as separate events. In contrast, we propose that citrullination can be viewed as the primary mechanism of autoimmunity, for instance by the formation of anti-citrullinated protein antibodies (ACPAs) but also as a process contributing to chronic inflammation. Therefore, citrullination could be at the center, connecting and impacting multiple inflammatory diseases in which ACPAs, NETs, or ecDNA have already been documented. In this review, we aimed to highlight the importance of citrullination in the etiopathogenesis of a number of chronic diseases and to explore the diagnostic, prognostic, and therapeutic potential of the citrullination-NET axis.
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来源期刊
Journal of Innate Immunity
Journal of Innate Immunity 医学-免疫学
CiteScore
10.50
自引率
1.90%
发文量
35
审稿时长
7.5 months
期刊介绍: The ''Journal of Innate Immunity'' is a bimonthly journal covering all aspects within the area of innate immunity, including evolution of the immune system, molecular biology of cells involved in innate immunity, pattern recognition and signals of ‘danger’, microbial corruption, host response and inflammation, mucosal immunity, complement and coagulation, sepsis and septic shock, molecular genomics, and development of immunotherapies. The journal publishes original research articles, short communications, reviews, commentaries and letters to the editors. In addition to regular papers, some issues feature a special section with a thematic focus.
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