转化生长因子β1在成釉细胞瘤、钙化性牙源性囊肿和牙源性角化囊肿中的表达评价

Q3 Dentistry

Journal of Orofacial Sciences Pub Date : 2020-01-01 DOI:10.4103/jofs.jofs_103_19

N. Saghravanian, N. Ghazi, Amirhosein Habibollahi, M. Shakeri

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引用次数: 1

摘要

引言：成釉细胞瘤是最常见的牙源性上皮肿瘤，具有局部侵袭性，可导致复发和恶变。牙源性囊肿是颌骨常见的病变，具有不同的生物学行为。牙源性角化囊肿（OKC）和钙化牙源性囊肿（COC）伴成釉细胞瘤样上皮（成釉细胞型）比其他牙源性囊肿更具侵袭性。因此，世界卫生组织将这些病变分类为牙源性肿瘤。转化生长因子β1（TGF-β1）是一种分泌蛋白，具有多种细胞功能，包括牙齿发育过程中的上皮分化和肿瘤发生等病理过程。在肿瘤发展的最初阶段，它可以作为一种强大的肿瘤抑制基因发挥作用。本研究的目的是评估TGF-β1在成釉细胞瘤、OKC和COC中的表达。材料与方法：应用免疫组织化学方法检测15例成釉细胞瘤、15例成釉质细胞瘤和15例成髓细胞瘤的上皮和基质细胞中TGF-β1的表达。结果：所有病变的上皮细胞和基质细胞均有不同程度的免疫反应。与OKCs相比，成釉细胞瘤和COCs的上皮细胞的免疫表达在统计学上显著降低，而OKCs的基质细胞的免疫反应性显著降低。COCs和成釉细胞瘤在基质细胞和上皮细胞免疫反应性方面没有统计学上的显著差异，这表明它们的生物学行为相似。结论：与OKCs相比，成釉细胞瘤和COCs上皮细胞中TGF-β1免疫表达降低可能与这些病变的原始表型和更具侵袭性的生物学行为有关。OK1Cs中TGF-β1的基质表达减少可以解释为其基质比其他研究的病变更疏松。

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Evaluation of Transforming Growth Factor Beta 1 Expression in Ameloblastoma, Calcifying Odontogenic Cyst and Odontogenic Keratocyst

Introduction: Ameloblastoma is the most common neoplasm of odontogenic epithelium with locally aggressive behavior resulting in recurrence and malignant transformation. Odontogenic cysts are common lesions of the jaws with different biological behavior. Odontogenic keratocyst (OKC) and calcifying odontogenic cyst (COC) with ameloblastoma-like epithelium (ameloblastic type) are more aggressive than other odontogenic cysts. Therefore, these lesions were classified as odontogenic tumors by WHO. Transforming growth factor beta 1 (TGF-β1) is a secretory protein with diverse cellular functions including epithelial differentiation during tooth development and pathological processes such as tumorigenesis. It can function as a strong tumor suppressor gene during initial stages of tumor development. The aim of this study was to evaluate the TGF-β1 expression in ameloblastoma, OKC and COC with varying biological behavior. Materials and Methods: We examined TGF-β1 expression in epithelial and stromal cells of 15OKCs, 15COCs (ameloblastic type) and 15 ameloblastomas by immunohistochemistry. Results: Immunoreactivity was observed in epithelial and stromal cells of all lesions with different degrees. There was statistically significant reduced immunoexpression in epithelial cells of ameloblastomas and COCs compared to OKCs, whereas significant reduced immunoreactivity was reported in stromal cells of OKCs. There was no statistically significant difference between COCs and ameloblastomas in both stromal and epithelial cells immunoreactivity which shows their similar bilological behavior. Conclusion: Reduced TGF-β1 immunoexpression in epithelial cells of ameloblastomas and COCs compared to OKCs could be associated with the primitive phenotype and more invasive biological behavior of these lesions. Reduced stromal expression of TGF-β1 in OK1Cs could be explained by its looser stroma than other studied lesions.

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来源期刊

Journal of Orofacial Sciences Dentistry-Orthodontics

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

31 weeks

期刊介绍： Journal of Orofacial Sciences is dedicated to noblest profession of Dentistry, and to the young & blossoming intellects of dentistry, with whom the future of dentistry will be cherished better. The prime aim of this journal is to advance the science and art of dentistry. This journal is an educational tool to encourage and share the acquired knowledge with our peers. It also to improves the standards and quality of therauptic methods. This journal assures you to gain knowledge in recent advances and research activities. The journal publishes original scientific papers with special emphasis on research, unusual case reports, editorial, review articles, book reviews & other relevant information in context of high professional standards.