{"title":"壳聚糖包覆CoFe2O4纳米粒子的结构与磁性研究","authors":"W. Mdlalose","doi":"10.33552/ABEB.2020.04.000589","DOIUrl":null,"url":null,"abstract":"Magnetic nanoparticles (MNPs) are currently explored for use in biomedical applications, such as in MRI, hyperthermia and drug delivery. In this study, CoFe 2 O 4 and its calcium-substituted derivative viz. CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs were synthesised via the glycol-thermal method. Furthermore, these MNPs were coated with chitosan (CS) to improve their biodegradability and biocompatibility. The anti-cancer drug, 5-fluorouracil (5-FU) was then loaded onto these MNPs to yield CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU and CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU. XRD results confirmed a single-phased cubic spinel structure for all MNPs. The naked MNPs displayed an average crystalline size of ~9.32 nm, which increased up to 18.20 nm upon coating. The VSM measurements recorded saturation magnetization values (Ms) of up to 73.951 emu/g. Upon polymer-coating, the shielding effect of chitosan resulted in reduced Ms of up to 17.220 emu/g in CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs. Release profiles were determined at pH 4.5 and 7.4 over a period of 72 hours. A faster release of the drug was noted at the acidic pH with an accumulative release of 91.00% in CS-CoFe2O4-5FU. Coupled with a strong recommendation for in vitro studies, these MNPs present as attractive candidates to complement current anti-cancer treatments.","PeriodicalId":72276,"journal":{"name":"Archives in biomedical engineering & biotechnology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Investigating the Structural and Magnetic Properties of Chitosan Coated CoFe2O4 Nanoparticles for Drug Delivery\",\"authors\":\"W. Mdlalose\",\"doi\":\"10.33552/ABEB.2020.04.000589\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Magnetic nanoparticles (MNPs) are currently explored for use in biomedical applications, such as in MRI, hyperthermia and drug delivery. In this study, CoFe 2 O 4 and its calcium-substituted derivative viz. CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs were synthesised via the glycol-thermal method. Furthermore, these MNPs were coated with chitosan (CS) to improve their biodegradability and biocompatibility. The anti-cancer drug, 5-fluorouracil (5-FU) was then loaded onto these MNPs to yield CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU and CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU. XRD results confirmed a single-phased cubic spinel structure for all MNPs. The naked MNPs displayed an average crystalline size of ~9.32 nm, which increased up to 18.20 nm upon coating. The VSM measurements recorded saturation magnetization values (Ms) of up to 73.951 emu/g. Upon polymer-coating, the shielding effect of chitosan resulted in reduced Ms of up to 17.220 emu/g in CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs. Release profiles were determined at pH 4.5 and 7.4 over a period of 72 hours. A faster release of the drug was noted at the acidic pH with an accumulative release of 91.00% in CS-CoFe2O4-5FU. Coupled with a strong recommendation for in vitro studies, these MNPs present as attractive candidates to complement current anti-cancer treatments.\",\"PeriodicalId\":72276,\"journal\":{\"name\":\"Archives in biomedical engineering & biotechnology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives in biomedical engineering & biotechnology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33552/ABEB.2020.04.000589\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives in biomedical engineering & biotechnology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33552/ABEB.2020.04.000589","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
磁性纳米颗粒(MNP)目前被探索用于生物医学应用,如MRI、热疗和药物递送。本研究采用乙二醇热法合成了CoFe2O4及其钙取代衍生物CS Ca 0.5 Co 0.5 Fe2O4 MNPs。此外,用壳聚糖(CS)包覆这些MNP以提高其生物降解性和生物相容性。然后将抗癌药物5-氟尿嘧啶(5-FU)负载到这些MNP上,得到CS-Ca 0.5 Co 0.5 Fe 2 O 4-5FU和CS-Ca 0.5 Co0.5 Fe 2 O 4-5FF。XRD结果证实了所有MNP的单相立方尖晶石结构。裸MNP显示出约9.32nm的平均晶体尺寸,在涂覆后增加到18.20nm。VSM测量记录的饱和磁化值(Ms)高达73.951emu/g。在聚合物涂层后,壳聚糖的屏蔽作用使CS Ca 0.5 Co 0.5 Fe 2 O 4 MNPs中的Ms降低了17.220 emu/g。在pH 4.5和7.4下测定72小时的释放曲线。在酸性pH下,药物释放更快,CS-CoFe2O4-5FU的累积释放率为91.00%。再加上强烈建议进行体外研究,这些MNP是补充当前抗癌治疗的有吸引力的候选药物。
Investigating the Structural and Magnetic Properties of Chitosan Coated CoFe2O4 Nanoparticles for Drug Delivery
Magnetic nanoparticles (MNPs) are currently explored for use in biomedical applications, such as in MRI, hyperthermia and drug delivery. In this study, CoFe 2 O 4 and its calcium-substituted derivative viz. CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs were synthesised via the glycol-thermal method. Furthermore, these MNPs were coated with chitosan (CS) to improve their biodegradability and biocompatibility. The anti-cancer drug, 5-fluorouracil (5-FU) was then loaded onto these MNPs to yield CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU and CS-Ca 0.5 Co 0.5 Fe 2 O 4 -5FU. XRD results confirmed a single-phased cubic spinel structure for all MNPs. The naked MNPs displayed an average crystalline size of ~9.32 nm, which increased up to 18.20 nm upon coating. The VSM measurements recorded saturation magnetization values (Ms) of up to 73.951 emu/g. Upon polymer-coating, the shielding effect of chitosan resulted in reduced Ms of up to 17.220 emu/g in CS-Ca 0.5 Co 0.5 Fe 2 O 4 MNPs. Release profiles were determined at pH 4.5 and 7.4 over a period of 72 hours. A faster release of the drug was noted at the acidic pH with an accumulative release of 91.00% in CS-CoFe2O4-5FU. Coupled with a strong recommendation for in vitro studies, these MNPs present as attractive candidates to complement current anti-cancer treatments.