干菊苣根改善肠道功能,有益于肠道微生物营养链,并增加2型糖尿病患者的粪便和循环短链脂肪酸

Gut microbiome (Cambridge, England) Pub Date : 2022-04-28 eCollection Date: 2022-01-01 DOI:10.1017/gmb.2022.4
Marie-Luise Puhlmann, Roosa Jokela, Katja Catharina Wilhelmina van Dongen, Thi Phuong Nam Bui, Roland Willem Jan van Hangelbroek, Hauke Smidt, Willem Meindert de Vos, Edith Johanna Maria Feskens
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引用次数: 0

摘要

我们在一项随机、安慰剂对照试验中研究了干菊苣根对肠道功能、肠道微生物群及其产物和葡萄糖稳态的影响,该试验有55名2型糖尿病风险受试者。处理后大便柔软度增加(+1.1±0.3个单位);P = 0.034)和排便次数(+0.6±0.2次/d);P < 0.001),强烈调节的肠道微生物群组成(7%的变化;p = 0.001),并且厌氧杆菌和双歧杆菌的相对水平以剂量依赖、可逆的方式显著增加(3-4倍)。一个合成群落,包括这些属和拟杆菌菌株的精选成员,从该产物产生了一个丁酸营养链。粪中乙酸、丙酸、丁酸增加25.8%(+13.0±6.3 mmol/kg);p = 0.023),空腹循环水平下降15.7%(+7.7±3.9 μM);P = 0.057)。在治疗组中,血糖变异系数从21.3±0.94下降到18.3±0.84% (p = 0.004),而空腹血糖和HOMA-ir在基线低Blautia水平的受试者中下降(- 0.3±0.1 mmol/L空腹血糖;P = 0.0187;−0.14±0.1 HOMA-ir;P = 0.045)。干菊苣根的摄入迅速和可逆地影响肠功能,有利于产丁营养链,并促进血糖控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dried chicory root improves bowel function, benefits intestinal microbial trophic chains and increases faecal and circulating short chain fatty acids in subjects at risk for type 2 diabetes.

We investigated the impact of dried chicory root in a randomised, placebo-controlled trial with 55 subjects at risk for type 2 diabetes on bowel function, gut microbiota and its products, and glucose homeostasis. The treatment increased stool softness (+1.1 ± 0.3 units; p = 0.034) and frequency (+0.6 ± 0.2 defecations/day; p < 0.001), strongly modulated gut microbiota composition (7 % variation; p = 0.001), and dramatically increased relative levels (3-4-fold) of Anaerostipes and Bifidobacterium spp., in a dose-dependent, reversible manner. A synthetic community, including selected members of these genera and a Bacteroides strain, generated a butyrogenic trophic chain from the product. Faecal acetate, propionate and butyrate increased by 25.8 % (+13.0 ± 6.3 mmol/kg; p = 0.023) as did their fasting circulating levels by 15.7 % (+7.7 ± 3.9 μM; p = 0.057). In the treatment group the glycaemic coefficient of variation decreased from 21.3 ± 0.94 to 18.3 ± 0.84 % (p = 0.004), whereas fasting glucose and HOMA-ir decreased in subjects with low baseline Blautia levels (-0.3 ± 0.1 mmol/L fasting glucose; p = 0.0187; -0.14 ± 0.1 HOMA-ir; p = 0.045). Dried chicory root intake rapidly and reversibly affects bowel function, benefits butyrogenic trophic chains, and promotes glycaemic control.

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